Query ChEMBL bioactive molecules and drug discovery data. Search compounds by structure/properties, retrieve bioactivity data (IC50, Ki), find inhibitors, perform SAR studies, for medicinal chemistry.
79
77%
Does it follow best practices?
Impact
74%
1.17xAverage score across 3 eval scenarios
Passed
No known issues
Optimize this skill with Tessl
npx tessl skill review --optimize ./scientific-skills/chembl-database/SKILL.mdQuality
Discovery
82%Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.
This is a strong, domain-specific description with excellent specificity and trigger term coverage for medicinal chemistry users. The main weakness is the absence of an explicit 'Use when...' clause, which would help Claude know exactly when to select this skill. The technical terminology is appropriate for the target audience and creates clear distinctiveness.
Suggestions
Add an explicit 'Use when...' clause, e.g., 'Use when the user asks about drug compounds, bioactivity data, chemical databases, or mentions ChEMBL, IC50, Ki values, or structure-activity relationships.'
| Dimension | Reasoning | Score |
|---|---|---|
Specificity | Lists multiple specific concrete actions: 'Search compounds by structure/properties', 'retrieve bioactivity data (IC50, Ki)', 'find inhibitors', 'perform SAR studies'. These are precise, domain-specific capabilities. | 3 / 3 |
Completeness | Clearly answers 'what does this do' with specific capabilities, but lacks an explicit 'Use when...' clause or equivalent trigger guidance. The 'when' is only implied through the domain context. | 2 / 3 |
Trigger Term Quality | Excellent coverage of natural terms a medicinal chemist would use: 'ChEMBL', 'bioactive molecules', 'drug discovery', 'compounds', 'IC50', 'Ki', 'inhibitors', 'SAR studies', 'medicinal chemistry'. These are the exact terms users in this domain would naturally say. | 3 / 3 |
Distinctiveness Conflict Risk | Highly distinctive with domain-specific terminology (ChEMBL, IC50, Ki, SAR) that creates a clear niche. Unlikely to conflict with other skills due to the specialized medicinal chemistry focus. | 3 / 3 |
Total | 11 / 12 Passed |
Implementation
72%Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.
This is a solid, actionable skill with excellent code examples and good progressive disclosure. The main weaknesses are some unnecessary explanatory content that Claude doesn't need (database description, use case enumeration) and missing validation/error handling in the workflows for API operations that could fail or return empty results.
Suggestions
Remove or significantly condense the Overview and 'When to Use This Skill' sections - Claude understands what ChEMBL is and when to query bioactivity databases
Add validation steps to workflows: check if results are empty, handle API errors, verify data quality flags before proceeding
Add a brief error handling pattern showing how to handle common API failures (rate limiting, empty results, invalid IDs)
| Dimension | Reasoning | Score |
|---|---|---|
Conciseness | The skill contains some unnecessary explanatory content (e.g., the Overview section explaining what ChEMBL is, the 'When to Use This Skill' section listing obvious use cases). However, the code examples are generally lean and the technical content is efficient. | 2 / 3 |
Actionability | Excellent executable code examples throughout - all Python snippets are copy-paste ready with proper imports, realistic parameters, and complete syntax. The workflows provide concrete, step-by-step code that can be directly executed. | 3 / 3 |
Workflow Clarity | Three workflows are clearly sequenced with numbered steps and code, but they lack validation checkpoints. For operations involving API queries that could fail or return unexpected results, there's no error handling, result validation, or feedback loops for recovery. | 2 / 3 |
Progressive Disclosure | Well-structured with clear sections progressing from basic to advanced. References to external files (scripts/example_queries.py, references/api_reference.md) are clearly signaled with descriptions of what each contains. Navigation is straightforward with one-level-deep references. | 3 / 3 |
Total | 10 / 12 Passed |
Validation
90%Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.
Validation — 10 / 11 Passed
Validation for skill structure
| Criteria | Description | Result |
|---|---|---|
metadata_version | 'metadata.version' is missing | Warning |
Total | 10 / 11 Passed | |
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Table of Contents
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