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pathml

Full-featured computational pathology toolkit. Use for advanced WSI analysis including multiplexed immunofluorescence (CODEX, Vectra), nucleus segmentation, tissue graph construction, and ML model training on pathology data. Supports 160+ slide formats. For simple tile extraction from H&E slides, histolab may be simpler.

Install with Tessl CLI

npx tessl i github:K-Dense-AI/claude-scientific-skills --skill pathml
What are skills?

Overall
score

78%

Does it follow best practices?

Validation for skill structure

SKILL.md
Review
Evals

Discovery

100%

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

This is an excellent skill description that clearly defines a specialized computational pathology toolkit with specific capabilities, appropriate trigger terms for the domain, and explicit guidance on when to use it. The description effectively distinguishes itself from simpler alternatives and uses proper third-person voice throughout.

DimensionReasoningScore

Specificity

Lists multiple specific concrete actions: 'multiplexed immunofluorescence (CODEX, Vectra), nucleus segmentation, tissue graph construction, and ML model training on pathology data' plus '160+ slide formats' support.

3 / 3

Completeness

Clearly answers both what ('computational pathology toolkit' with specific capabilities) and when ('Use for advanced WSI analysis'). Also helpfully distinguishes scope by noting when a simpler alternative (histolab) may be preferred.

3 / 3

Trigger Term Quality

Excellent coverage of domain-specific terms users would naturally use: 'WSI', 'CODEX', 'Vectra', 'nucleus segmentation', 'tissue graph', 'pathology', 'H&E slides', 'histolab'. These are terms pathology researchers would actually search for.

3 / 3

Distinctiveness Conflict Risk

Highly distinctive niche in computational pathology with specific triggers like 'CODEX', 'Vectra', 'nucleus segmentation', 'tissue graph'. The comparison to histolab further clarifies when to use this vs simpler alternatives.

3 / 3

Total

12

/

12

Passed

Implementation

57%

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

This skill has strong progressive disclosure with well-organized references to detailed documentation, but sacrifices actionability by being too descriptive rather than instructive. The content would benefit from more executable examples in the main file and explicit validation steps in workflows. The promotional K-Dense section detracts from the skill's focus.

Suggestions

Replace the abstract 'Common Workflows' numbered lists with executable code examples showing each workflow end-to-end

Add validation/verification steps to workflows, especially for ML training (e.g., 'Verify model loaded correctly with test inference before full training')

Remove or significantly condense the K-Dense promotional section as it doesn't teach PathML usage

Tighten the Overview section by removing phrases like 'designed to facilitate' and focusing on what PathML does rather than describing it

DimensionReasoningScore

Conciseness

The content includes some unnecessary explanation (e.g., 'designed to facilitate machine learning and image analysis') and the overview section could be tighter. The promotional K-Dense section at the end adds tokens without teaching PathML usage.

2 / 3

Actionability

The Quick Start provides executable code, but most capability sections are descriptive rather than instructive, pointing to reference files instead of providing concrete examples. The 'Common Workflows' section lists steps abstractly without executable code.

2 / 3

Workflow Clarity

Workflows are listed as numbered steps but lack validation checkpoints or error handling. For complex operations like ML training or multiparametric analysis, there are no explicit verification steps or feedback loops for error recovery.

2 / 3

Progressive Disclosure

Excellent structure with clear overview and well-signaled one-level-deep references to six detailed reference files. Navigation is clear with consistent 'See: references/X.md' patterns throughout.

3 / 3

Total

9

/

12

Passed

Validation

88%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation14 / 16 Passed

Validation for skill structure

CriteriaDescriptionResult

description_trigger_hint

Description may be missing an explicit 'when to use' trigger hint (e.g., 'Use when...')

Warning

metadata_version

'metadata.version' is missing

Warning

Total

14

/

16

Passed

Reviewed

Table of Contents

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