Microsoft 365 tenant administration for Global Administrators. Automate M365 tenant setup, Office 365 admin tasks, Azure AD user management, Exchange Online configuration, Teams administration, and security policies. Generate PowerShell scripts for bulk operations, Conditional Access policies, license management, and compliance reporting. Use for M365 tenant manager, Office 365 admin, Azure AD users, Global Administrator, tenant configuration, or Microsoft 365 automation.

Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

Navigate, manage, and optimize monorepos. Covers Turborepo, Nx, pnpm workspaces, and Lerna. Cross-package impact analysis, selective builds/tests on affected packages, remote caching, dependency graph visualization, and structured multi-repo to monorepo migrations. Use when setting up a new monorepo, optimizing CI for a large workspace, debugging cross-package dependency issues, or planning a multi-repo consolidation.

Use when the user asks to write code efficiently, avoid over-engineering, reduce dependencies, or prevent unnecessary abstractions. Enforces a strict efficiency ladder: YAGNI, reuse, stdlib, native platform, existing deps — before writing any new code.

Zero-downtime migration planning, compatibility validation, and rollback strategy generation. Tools for system, database, and infrastructure migrations with minimal business impact. Use when planning a database migration, infrastructure cutover, system replacement, or any high-risk transition that needs explicit rollback paths.

Designs studies for predicting treatment response or resistance in biomedical and clinical research. Always use this skill when the user needs a treatment-response or resistance prediction study blueprint rather than a prognostic biomarker protocol, diagnostic test design, causal treatment-effect estimation, or a completed manuscript. Focus on responder definition, treatment context, baseline comparability, feature integration strategy, model development logic, validation architecture, and interpretation boundaries. Do not invent response rates, cohort size, assay readiness, regimen uniformity, literature support, or validation access.

Migrate from Cypress or Selenium to Playwright. Use when user mentions "cypress", "selenium", "migrate tests", "convert tests", "switch to playwright", "move from cypress", or "replace selenium".

Merge the winning agent's branch into base, archive losers, and clean up worktrees. Use when the user runs /hub:merge or asks to land the winning AgentHub result and tidy the session.

Designs a translational blueprint for moving a biomedical finding toward diagnosis, prognosis, treatment response prediction, patient stratification, or therapeutic development, with explicit translational milestones, validation thresholds, and feasibility-sensitive route framing.

Memory health dashboard showing line counts, topic files, capacity, stale entries, and recommendations. Use when the user runs /si:memory-status or asks how full or healthy the agent memory is.

Analyze auto-memory for promotion candidates, stale entries, consolidation opportunities, and health metrics. Use when the user runs /si:memory-review or asks what has been learned and what should be promoted or pruned.

Use when designing, reviewing, or paying for an agent memory system — adding memory to an agent, choosing between long-context / RAG / graph / agentic memory, auditing what a CLAUDE.md or memory directory actually holds, deciding what to keep and what to expire, or when a memory store keeps growing and nobody has said what leaves it. Prices the write path, picks which cost to pay, classifies records as facts / skills / logs, and refuses a design that has no forgetting policy.

Refines broad, vague, or aspirational biomedical research objectives into clear, bounded, measurable, executable, and downstream-ready study objective statements. Always use this skill when a user has a general aim such as “explore a mechanism,” “study prognosis,” “investigate biomarkers,” or “look at treatment response,” but the objective is still too broad, non-operational, or too ambiguous to support protocol framing, design selection, analysis planning, or hypothesis design. Never assume that polished wording alone means the objective is actionable. Focus first on objective type, missing operational elements, scope discipline, and downstream-ready formulation.

Use when someone wants to decide whether a meeting is worth calling, price a meeting in dollars, build a timeboxed agenda with desired outcomes, or turn messy meeting notes into owned action items — or says "should this be a meeting", "/cs:meeting-prep", or "/cs:meeting-actions". Runs a cost gate (ASYNC / NOT-READY / MEET), builds a decision-first agenda, and extracts an owner + due-date checklist that flags every orphan.

Analyzes meeting transcripts and recordings to surface behavioral patterns, communication anti-patterns, and actionable coaching feedback. Use this skill whenever the user uploads or points to meeting transcripts (.txt, .md, .vtt, .srt, .docx), asks about their communication habits, wants feedback on how they run meetings, requests speaking ratio analysis, mentions filler words or conflict avoidance, or wants to compare their communication across time periods. Also trigger when users mention tools like Granola, Otter, Fireflies, or Zoom transcripts. Even if the user just says "look at my meetings" or "how do I come across in meetings" — use this skill.

Generates complete conventional single-gene oncology research designs from a user-provided cancer context, target gene, and validation direction. Use when a study centers on a fixed candidate gene and needs expression, prognosis, clinicopathologic association, functional interpretation, immune context, genomic or epigenetic context, optional drug-response hypotheses, and orthogonal validation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

EU MDR 2017/745 compliance specialist for medical device classification, technical documentation, clinical evidence, and post-market surveillance. Covers Annex VIII classification rules, Annex II/III technical files, Annex XIV clinical evaluation, Art. 86 PSUR schedules, and EUDAMED integration. Use when classifying a medical device under MDR, building or gap-checking a technical file, planning clinical evaluation or PMS/PSUR cadence, or preparing for notified body review (e.g., 'what class is my device under MDR', 'review my PSUR schedule').

Converts a markdown deck (slides separated by `---` HR boundaries or by `# ` H1 headings, with optional `<!-- notes: ... -->` presenter notes blocks) into a single-file HTML presentation with arrow-key / space / PgDn / PgUp / Home / End / P / Esc keyboard navigation, presenter mode (split view with current slide + speaker notes + clock + next-slide preview), URL-hash deep linking, and `@media print` page-per-slide for PDF export. Triggers when the markdown-html-orchestrator classifies an input as SLIDES, or when invoked directly via /cs:md-slides. Reuses md-document's markdown parser for slide-body rendering and reads design-system tokens via config_loader.py. Refuses if input has no clear slide boundaries, produces a 1-slide deck, or `--strict-notes` is on with < 50% notes coverage. Use after orchestrator routing.

Converts a markdown PR writeup or code review (one with ```diff fenced blocks and severity-tagged > [!BLOCKER]/[!MAJOR]/[!MINOR]/[!NIT] callouts) into a single-file 2-column HTML review — unified-diff on the left, severity-tagged annotation cards on the right, top jump-nav listing every finding, mandatory named reviewer footer. Triggers when the markdown-html-orchestrator classifies an input as REVIEW, or when invoked directly via /cs:md-review. Refuses without explicit --reviewer (a code review must name a human), refuses if no diff hunks present (route to md-document instead), and refuses to encode severity in color only (every badge ships color + icon + aria-label per WCAG 1.4.1). Use after orchestrator routing.

Generates complete FAERS pharmacovigilance study designs for one-drug whole-profile safety mapping using signal detection, subgroup analysis, onset/seriousness characterization, and conservative label-gap interpretation.