Track and optimize application response times across API endpoints, database queries, and service calls. Use when monitoring performance or identifying bottlenecks. Trigger with phrases like "track response times", "monitor API performance", or "analyze latency".

Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching.

Generate gRPC service definitions, stubs, and implementations from Protocol Buffers. Use when creating high-performance gRPC services. Trigger with phrases like "generate gRPC service", "create gRPC API", or "build gRPC server".

Manage Firebase/Firestore operations including CRUD, queries, batch processing, and index/rule guidance. Use when you need to create/update/query Firestore documents, run batch writes, troubleshoot missing indexes, or plan migrations. Trigger with phrases like "firestore operations", "create firestore document", "batch write", "missing index", or "fix firestore query".

Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminformatics.

Review UI code for Web Interface Guidelines compliance. Use when asked to "review my UI", "check accessibility", "audit design", "review UX", or "check my site against best practices". Fetches latest Vercel guidelines and checks files against all rules.

Build reusable, maintainable UI components following modern design patterns. Use when creating component libraries, implementing design systems, or building scalable frontend architectures. Handles React patterns, composition, prop design, TypeScript, and component best practices.

Automatically updates regression tests based on interval analysis to maintain coverage of key program intervals. Use when code changes affect value ranges, conditionals, or control flow, and existing tests need updating to maintain interval coverage. Analyzes interval information from updated code, identifies coverage gaps, adjusts test inputs and assertions, removes redundant tests, and generates new tests for uncovered intervals. Supports Python, Java, JavaScript, and C/C++ with various test frameworks (pytest, JUnit, Jest, Google Test).

Master defensive Bash programming techniques for production-grade scripts. Use when writing robust shell scripts, CI/CD pipelines, or system utilities requiring fault tolerance and safety.

Access European Nucleotide Archive via API/FTP. Retrieve DNA/RNA sequences, raw reads (FASTQ), genome assemblies by accession, for genomics and bioinformatics pipelines. Supports multiple formats.

Use when the user explicitly asks for a desktop or system screenshot (full screen, specific app or window, or a pixel region), or when tool-specific capture capabilities are unavailable and an OS-level capture is needed.

Write comprehensive backend tests including unit tests, integration tests, and API tests. Use when testing REST APIs, database operations, authentication flows, or business logic. Handles Jest, Pytest, Mocha, testing strategies, mocking, and test coverage.

Create comprehensive API documentation with examples, authentication guides, and SDKs. Use when creating comprehensive API documentation. Trigger with phrases like "generate API docs", "create API documentation", or "document the API".

Use this skill when writing new features, fixing bugs, or refactoring code. Enforces test-driven development with 80%+ coverage including unit, integration, and E2E tests.

Smart dependency management for any language. Auto-detects project type, applies safe updates automatically, prompts for major versions, diagnoses and fixes dependency issues.

Smart dependency management for any language. Auto-detects project type, applies safe updates automatically, prompts for major versions, diagnoses and fixes dependency issues.

UWP-to-WinUI 3 migration reference. Maps legacy UWP APIs to correct Windows App SDK equivalents with before/after code snippets. Covers namespace changes, threading (CoreDispatcher to DispatcherQueue), windowing (CoreWindow to AppWindow), dialogs, pickers, sharing, printing, background tasks, and the most common Copilot code generation mistakes.

Guidance for instrumenting webapps with Azure Application Insights. Provides telemetry patterns, SDK setup, and configuration references. WHEN: how to instrument app, App Insights SDK, telemetry patterns, what is App Insights, Application Insights guidance, instrumentation examples, APM best practices.

This skill should be used when the user asks to "plan this", "make a plan", "create an implementation plan", "how should I implement", "design the implementation", "plan the refactor", "plan the migration", "plan the feature", "break this down into steps", "implementation strategy", "deep plan", "thorough plan", or wants a thorough, multi-phase implementation plan with codebase exploration before writing any code.