Enable Supervisor API background mode for long-running agent tasks. Use when: (1) Agent needs to run tasks longer than HTTP timeout limits, (2) User says 'background mode', 'long-running', 'supervisor api', (3) Converting from streaming to background polling pattern, (4) Agent needs resilience to connection drops during execution.

Guide secure migration of code from memory-unsafe languages (C, C++, Assembly) to memory-safe languages (Rust, Go, Java, C#, Swift). Use when migrating or rewriting legacy C/C++ code, designing FFI boundaries between safe and unsafe code, writing new modules in existing C/C++ codebases, reviewing mixed-language projects, planning memory safety roadmaps, or when an AI agent is about to generate new C/C++ code that could be written in a memory-safe language instead. Also triggers on CISA/NSA memory safety compliance discussions.

Create new skills, modify and improve existing skills, and measure skill performance. Use when users want to create a skill from scratch for Claude Code or Cursor, update or optimize an existing skill, run evals to test a skill, benchmark skill performance with variance analysis, or optimize a skill's description for better triggering accuracy.

Use when working on or reviewing session execution, command handling, shell state, FIFO-based streaming, or stdout/stderr separation. Relevant for session.ts, command handlers, exec/execStream, or anything involving shell process management. (project)

Interview the user relentlessly about a plan or design until reaching shared understanding, resolving each branch of the decision tree. Use when user wants to stress-test a plan, get grilled on their design, or mentions "grill me".

Scan reagent barcodes or IDs, log expiration dates, and generate multi-level alerts before reagent expiry to support laboratory inventory management.

Generate offline interactive mindmap HTML and convert Markdown, outlines, meeting notes, chapter structures, or JSON trees into markmap-compatible format. Use when organizing long text into mindmaps, converting meeting notes to mindmap pages, generating final HTML via markmap-cli, or adding browsable mindmaps to deliverables.

Generate professional Key Visual (KV) design proposals and images; use when you have a slogan/copy and a marketing scenario but need a clear visual direction and a ready-to-generate image prompt.

Complete workflow for generating academic research posters from PDF literature; use when you need to extract paper content from PDFs and produce a LaTeX-based poster (beamerposter/tikzposter/baposter) with mandatory figure generation and a final rendered HTML deliverable.

Access the European Nucleotide Archive (ENA) via REST APIs and FTP/Aspera to search and retrieve sequences, raw reads (FASTQ), assemblies, and metadata when you have accession IDs or need metadata-driven discovery for genomics pipelines.

Programmatically query the CZ CELLxGENE Census (61M+ cells) when you need cross-tissue, disease, or cell-type expression data for population-scale queries and reference atlas comparisons.

Guided statistical analysis for test selection, assumption checks, power analysis, and APA-style reporting. Use when you need to choose an appropriate statistical test for your data and produce publication-ready results (including effect sizes and diagnostics).

Differential gene expression analysis for bulk RNA-seq count matrices using a DESeq2-like workflow in Python; use when you need Wald tests, FDR correction, and optional LFC shrinkage for condition/batch/covariate designs.

Unified Python access to 40+ bioinformatics web services; use when you need to query multiple databases (e.g., UniProt/KEGG/ChEMBL/Reactome) with one consistent API in a single workflow, especially for cross-database analysis and identifier mapping.

Sequence alignment and alignment file processing with Biopython (Bio.Align/Bio.AlignIO), triggered when you need global/local pairwise alignment, MSA read/write/format conversion, or alignment statistics/filtering.

Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instrum...

Rewrite drafts according to target writing style or target journal format. Triggers when user says "rewrite in XX style", "match this tone", "format for XX journal", "rewrite following this format". Input can be .docx / .md / .txt or conversation text.

Write comprehensive literature reviews for medical imaging AI research. Use when writing survey papers, systematic reviews, or literature analyses on topics like segmentation, detection, classification in CT, MRI, X-ray, ultrasound, or pathology imaging. Triggers on requests f...

Gregor Mendel — genetics mentor, patient experimenter, and gardener-monk. Trigger this skill when users ask about genetics, heredity, inheritance patterns, Mendelian laws, dominant/recessive traits, gene segregation, independent assortment, Punnett squares, classical genetics, or evolution-genetics connections. Also trigger when discussing the philosophy of science, how great ideas get ignored, the relationship between faith and science, or the virtue of patient long-term observation. Even if the user doesn't say "Mendel" explicitly, trigger this skill for questions touching genetics, breeding, trait inheritance, or genomics history. Part of the AIPOCH Science Mentor Skill Hub.

Use when analyzing transcription factor (TF) regulatory networks using Dorothea database. Input gene list, identify regulating transcription factors, generate TF-Target network visualization. For: transcription factor enrichment analysis, gene regulatory network research.