gwas-database

Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-values and summary statistics, for genetic epidemiology and polygenic risk scores.

1.09x

Quality

66%

Does it follow best practices?

Impact

96%

1.09x

Average score across 3 eval scenarios

Securityby

Passed

No known issues

Optimize this skill with Tessl

npx tessl skill review --optimize ./scientific-skills/gwas-database/SKILL.md

Evaluation results

92%

Genetic Risk Variant Report for Coronary Artery Disease

Disease association querying with pagination

Criteria

Without context

With context

Correct API base URL

100%

EFO trait identifier used

100%

Content-Type header present

100%

_embedded response parsing

100%

Pagination implemented

100%

Rate limiting present

100%

Genome-wide significance filter

100%

rsId field extracted

50%

62%

p-value field extracted

100%

Risk allele field extracted

50%

37%

Effect size field extracted

100%

96%

Investigating Pleiotropic Effects of a Metabolic Risk Variant

SNP pleiotropy investigation

Criteria

Without context

With context

Correct variant endpoint

100%

rs number as identifier

100%

associationBySnp projection

100%

Content-Type header present

100%

_embedded response parsing

100%

_links navigation used

100%

efoTrait field extracted

90%

80%

p-value field extracted

100%

Risk allele field extracted

75%

Correct API base URL

100%

Fine-Mapping a Genomic Locus for Inflammatory Bowel Disease

Genomic region query and summary statistics filtering

Criteria

Without context

With context

Region query endpoint

100%

Region query parameters

100%

Summary Statistics API base URL

100%

p_upper parameter used

100%

Gene query endpoint

100%

geneName parameter used

100%

Main API base URL

100%

Content-Type header present

100%

_embedded response parsing

100%

Three distinct result files

100%

Repository: K-Dense-AI/claude-scientific-skills
Commit: 71add64

Evaluated: 27 days ago
Agent: Claude Code
Model: Claude Sonnet 4.6

Table of Contents

Genetic Risk Variant Report for Coronary Artery Disease Investigating Pleiotropic Effects of a Metabolic Risk Variant Fine-Mapping a Genomic Locus for Inflammatory Bowel Disease

Is this your skill?

If you maintain this skill, you can claim it as your own. Once claimed, you can manage eval scenarios, bundle related skills, attach documentation or rules, and ensure cross-agent compatibility.