opentargets-database

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

1.67x

Quality

76%

Does it follow best practices?

Impact

92%

1.67x

Average score across 3 eval scenarios

Securityby

Advisory

Suggest reviewing before use

Optimize this skill with Tessl

npx tessl skill review --optimize ./scientific-skills/opentargets-database/SKILL.md

Evaluation results

100%

29%

Parkinson's Disease Target Prioritization

Target discovery workflow

Criteria

Without context

With context

Uses helper scripts

100%

Searches for disease first

100%

Queries disease with targets

80%

100%

Retrieves detailed target info

100%

Examines evidence types

100%

Score interpretation note

100%

Tractability assessment

100%

Safety or constraint assessment

90%

100%

Error handling in script

100%

Under-studied disease caveat

50%

100%

96%

44%

Drug Repurposing Investigation for Pulmonary Arterial Hypertension

Drug repurposing workflow

Criteria

Without context

With context

Uses helper scripts

83%

Searches for disease EFO ID

100%

Calls get_known_drugs_for_disease

100%

Calls get_drug_info for individual drugs

100%

Uses ChEMBL ID for drug lookup

100%

Clinical phase interpretation

100%

Mechanism of action examined

100%

Related indications for repurposing

100%

Summary statistics included

50%

100%

API error handling

100%

80%

36%

Target Validation Assessment for AML Drug Discovery

Target validation with safety and tractability

Criteria

Without context

With context

Uses helper scripts

70%

Searches for target Ensembl ID

87%

Retrieves target info with diseases

87%

Tractability levels present

50%

70%

Safety liabilities examined

80%

70%

Genetic constraint data

90%

Evidence type breakdown

90%

Expert-curated sources highlighted

12%

75%

Score caveat present

37%

87%

L2G score or GWAS causal gene note

25%

62%

Gets evidence for AML association

70%

90%

Repository: K-Dense-AI/claude-scientific-skills
Commit: 71add64

Evaluated: 27 days ago
Agent: Claude Code
Model: Claude Sonnet 4.6

Table of Contents

Parkinson's Disease Target Prioritization Drug Repurposing Investigation for Pulmonary Arterial Hypertension Target Validation Assessment for AML Drug Discovery

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