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evo2

Score, embed, and generate DNA sequences with Evo 2, a long-context genomic foundation model. Use this skill when: (1) Computing per-nucleotide or per-sequence likelihoods for variant effect scoring, (2) Embedding genomic windows for downstream classification, (3) Generating DNA conditioned on a prefix, (4) Scoring regulatory or coding regions across species.

68

Quality

84%

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SKILL.md
Quality
Evals
Security

Quality

Content

76%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A lean, highly actionable reference with executable code, useful model/VRAM tables, and a well-sequenced remote-compute workflow. Its main gaps are the unshown score_evo2.py job script and the absence of an explicit result-verification checkpoint in the batch scoring workflow, which caps workflow clarity.

Suggestions

Add a verification checkpoint after the compute_done notification (e.g., inspect scores.json for expected length/range before calling save_artifacts) so the batch scoring workflow has an explicit validation step.

Include the contents of score_evo2.py (or a skeleton showing the HF_HOME/HF_HUB_OFFLINE setup and score_sequences call) so the remote-compute example is fully copy-paste ready.

Move the troubleshooting and typical-performance tables into a reference file to keep SKILL.md as a tighter overview, since no bundle files currently exist.

DimensionReasoningScore

Conciseness

The body is dense tables and executable code with zero explanations of concepts Claude already knows; even prose lines carry non-obvious operational facts ('set HF_HUB_OFFLINE=1 so the loader doesn't try to write refs/ into a read-only mount', 'More negative ⇒ less likely under the model'). Every token earns its place, matching anchor 5 rather than the minor-trimming of anchor 4.

5 / 5

Actionability

Most guidance is executable — 'pip install evo2', 'Evo2("evo2_7b")', 'model.score_sequences(seqs)', 'model.generate(prompt_seqs=[...])', and a concrete submit_job call — but 'score_evo2.py' is passed as a job input without its contents being shown, and 'env selection is host-specific' leaves a gap. This fits anchor 4 (mostly executable with minor gaps), not 5, because the pivotal scoring script is referenced rather than provided.

4 / 5

Workflow Clarity

The remote-compute sequence is clearly ordered (read compute_details → create provider → submit_job → wait_for_notification → save_artifacts → attach_job) and the troubleshooting table provides error recovery, but this is a batch workflow ('score_sequences, 200×200bp') with no explicit verification of job results before acting on the payload. Per the rubric's cap on batch operations lacking validation, this sits at anchor 3, not 4.

3 / 5

Progressive Disclosure

No bundle files exist; the single SKILL.md is well-sectioned (Prerequisites, How to run, Models, Output format, Decision tree, Remote compute, Performance, Troubleshooting) and defers orchestration detail to clearly-named one-level-deep external skills ('remote-compute-ssh' / 'remote-compute-modal'). At ~125 lines, some content (troubleshooting and performance tables) could live in reference files, fitting anchor 4 rather than the clean split of anchor 5.

4 / 5

Total

16

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong description: it states concrete capabilities in third person, explicitly enumerates four 'use when' triggers, and clearly delimits the DNA-genomic-model niche. The only weakness is modest synonym coverage in trigger terms (e.g., 'mutation' or 'ref/alt' phrasing is absent).

DimensionReasoningScore

Specificity

The description lists multiple concrete actions — 'Score, embed, and generate DNA sequences', 'Computing per-nucleotide or per-sequence likelihoods for variant effect scoring', 'Embedding genomic windows for downstream classification', 'Generating DNA conditioned on a prefix' — covering all the model's modes comprehensively, matching the anchor for multiple specific concrete actions with comprehensive coverage. It is not 4 because there is no noticeable gap in the action coverage.

5 / 5

Completeness

It explicitly answers both questions: 'what' via 'Score, embed, and generate DNA sequences with Evo 2, a long-context genomic foundation model' and 'when' via 'Use this skill when: (1)...(4)' with four concrete trigger cases. This matches anchor 5; it is not 4 because the 'when' is fully explicit and enumerated rather than merely present.

5 / 5

Trigger Term Quality

Natural domain terms are present ('DNA sequences', 'variant effect', 'embed', 'generate DNA') and the four enumerated use cases map well to what a genomics user would ask for, but common synonyms and variations ('mutation', 'ref/alt scoring', 'genome language model') are missing. Good coverage with a few natural terms absent fits anchor 4, not the comprehensive synonym coverage of anchor 5.

4 / 5

Distinctiveness Conflict Risk

'Evo 2, a long-context genomic foundation model' plus DNA-specific triggers (variant effect scoring, embedding genomic windows, prefix-conditioned DNA generation) carve a clear niche that would not fire for protein models or expression-track predictors. Clear niche with distinct triggers and minimal conflict risk matches anchor 5.

5 / 5

Total

19

/

20

Passed

Validation

81%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 13 / 16 Passed

Validation for skill structure

CriteriaDescriptionResult

metadata_version

'metadata.version' is missing

Warning

metadata_field

'metadata' should map string keys to string values

Warning

frontmatter_unknown_keys

Unknown frontmatter key(s) found; consider removing or moving to metadata

Warning

Total

13

/

16

Passed

Repository
UnicomAI/wanwu
Reviewed

Table of Contents

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