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go-kegg-enrichment

Performs GO (Gene Ontology) and KEGG pathway enrichment analysis on gene lists. Trigger when: - User provides a list of genes (symbols or IDs) and asks for enrichment analysis - User mentions "GO enrichment", "KEGG enrichment", "pathway analysis" - User wants to understand biological functions of gene sets - User provides differentially expressed genes (DEGs) and asks for interpretation - Input: gene list (file or inline), organism (human/mouse/rat), background gene set (optional) - Output: enriched terms, statistics, visualizations (barplot, dotplot, enrichment map)

82

1.00x
Quality

82%

Does it follow best practices?

Impact

72%

1.00x

Average score across 3 eval scenarios

SecuritybySnyk

Passed

No known issues

SKILL.md
Quality
Evals
Security

Evaluation results

76%

14%

Human Cancer Gene GO Enrichment Analysis

GO enrichment via gseapy pipeline

Criteria
Without context
With context

Uses gseapy library

100%

100%

Uses main.py script

0%

33%

Correct --genes argument

0%

37%

Human organism specified

50%

62%

GO analysis requested

62%

75%

Output directory set

62%

75%

Output directory created

50%

50%

GO result CSV files

100%

100%

Visualization files produced

100%

100%

REPORT.txt produced

50%

100%

analysis_notes.txt documents package

100%

100%

Without context: $0.3723 · 2m · 21 turns · 22 in / 6,621 out tokens

With context: $1.0430 · 3m 16s · 33 turns · 36 in / 11,068 out tokens

95%

18%

Mouse Immune Response KEGG Pathway Analysis

KEGG pathway analysis with background gene set

Criteria
Without context
With context

Uses main.py script

0%

50%

Mouse organism specified

80%

100%

KEGG analysis selected

80%

100%

Background gene set provided

86%

100%

Background documented

100%

100%

Stringent q-value cutoff

90%

100%

Correct output directory

87%

100%

KEGG results CSV

50%

100%

Q-value cutoff documented

100%

100%

Significant pathways reported

100%

100%

Without context: $0.6121 · 2m 32s · 29 turns · 34 in / 7,588 out tokens

With context: $1.1004 · 3m 20s · 33 turns · 210 in / 9,645 out tokens

46%

-31%

Quick GO Function Analysis for Neurodegeneration Genes

Enrichr API mode with selective GO ontologies

Criteria
Without context
With context

Uses Enrichr API flag

0%

0%

Online API documented

100%

100%

GO-only analysis

50%

0%

Selective ontologies

100%

0%

Custom p-value cutoff

80%

0%

P-value cutoff documented

100%

100%

Q-value cutoff documented

100%

100%

Ontologies documented

100%

100%

Output directory correct

87%

50%

Results per ontology reported

100%

100%

Without context: $0.2991 · 1m 23s · 19 turns · 23 in / 4,265 out tokens

With context: $0.9265 · 2m 54s · 35 turns · 246 in / 8,348 out tokens

Repository
aipoch/medical-research-skills
Evaluated
Agent
Claude Code
Model
Claude Sonnet 4.6

Table of Contents

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