Source: https://github.com/aipoch/medical-research-skills

Survival Analysis (Kaplan-Meier)

Kaplan-Meier survival analysis tool for clinical and biological research. Generates publication-ready survival curves with statistical tests.

When to Use

• Use this skill when the task needs Kaplan-Meier survival analysis tool for clinical and biological research. Generates publication-ready survival curves with statistical tests.
• Use this skill for data analysis tasks that require explicit assumptions, bounded scope, and a reproducible output format.
• Use this skill when you need a documented fallback path for missing inputs, execution errors, or partial evidence.

Key Features

See ## Features above for related details.

• Scope-focused workflow aligned to: Kaplan-Meier survival analysis tool for clinical and biological research. Generates publication-ready survival curves with statistical tests.
• Packaged executable path(s): scripts/main.py.
• Reference material available in references/ for task-specific guidance.
• Structured execution path designed to keep outputs consistent and reviewable.

Dependencies

• lifelines: Core survival analysis library
• matplotlib, seaborn: Visualization
• pandas, numpy: Data handling
• scipy: Statistical tests

Example Usage

See ## Usage above for related details.

cd "20260318/scientific-skills/Data Analytics/survival-analysis-km"
python -m py_compile scripts/main.py
python scripts/main.py --help

Example run plan:

1. Confirm the user input, output path, and any required config values.
2. Edit the in-file CONFIG block or documented parameters if the script uses fixed settings.
3. Run python scripts/main.py with the validated inputs.
4. Review the generated output and return the final artifact with any assumptions called out.

Implementation Details

See ## Workflow above for related details.

• Execution model: validate the request, choose the packaged workflow, and produce a bounded deliverable.
• Input controls: confirm the source files, scope limits, output format, and acceptance criteria before running any script.
• Primary implementation surface: scripts/main.py.
• Reference guidance: references/ contains supporting rules, prompts, or checklists.
• Parameters to clarify first: input path, output path, scope filters, thresholds, and any domain-specific constraints.
• Output discipline: keep results reproducible, identify assumptions explicitly, and avoid undocumented side effects.

Quick Check

Use this command to verify that the packaged script entry point can be parsed before deeper execution.

python -m py_compile scripts/main.py

Audit-Ready Commands

Use these concrete commands for validation. They are intentionally self-contained and avoid placeholder paths.

python -m py_compile scripts/main.py

# Example invocation: python scripts/main.py --help

# Example invocation: python scripts/main.py --input "Audit validation sample with explicit symptoms, history, assessment, and next-step plan."

Workflow

1. Confirm the user objective, required inputs, and non-negotiable constraints before doing detailed work.
2. Validate that the request matches the documented scope and stop early if the task would require unsupported assumptions.
3. Use the packaged script path or the documented reasoning path with only the inputs that are actually available.
4. Return a structured result that separates assumptions, deliverables, risks, and unresolved items.
5. If execution fails or inputs are incomplete, switch to the fallback path and state exactly what blocked full completion.

Features

• Kaplan-Meier Curve Generation: Publication-quality survival plots with confidence intervals
• Statistical Tests: Log-rank test, Wilcoxon test, Peto-Peto test
• Hazard Ratios: Cox proportional hazards regression with 95% CI
• Summary Statistics: Median survival time, restricted mean survival time (RMST)
• Multi-group Analysis: Supports 2+ comparison groups
• Risk Tables: Optional at-risk table below curves

Usage

Python Script

# Example invocation: python scripts/main.py --input data.csv --time time_col --event event_col --group group_col --output results/

Arguments

Input Format

CSV with columns:

• Time column: Numeric, time to event or censoring
• Event column: Binary (1 = event occurred, 0 = censored/right-censored)
• Group column: Categorical variable for stratification

Example:

patient_id,time_months,death,treatment_group
P001,24.5,1,Drug_A
P002,36.2,0,Drug_A
P003,18.7,1,Placebo

Output Files

• km_curve.png: Kaplan-Meier survival curve
• km_curve.pdf: Vector version for publications
• survival_stats.csv: Statistical summary (median survival, confidence intervals)
• hazard_ratios.csv: Cox regression results with HR and 95% CI
• `logrank_test.csv**: Pairwise comparison p-values
• `report.txt**: Human-readable summary report

Technical Details

Statistical Methods

1. Kaplan-Meier Estimator: Non-parametric maximum likelihood estimate of survival function

   • Product-limit estimator: Ŝ(t) = Π(tᵢ≤t) (1 - dᵢ/nᵢ)
   • Greenwood's formula for variance estimation

2. Log-Rank Test: Most widely used test for comparing survival curves

   • Null hypothesis: No difference between groups
   • Weighted by number at risk at each event time

3. Cox Proportional Hazards: Semi-parametric regression model

   • h(t|X) = h₀(t) × exp(β₁X₁ + β₂X₂ + ...)
   • Proportional hazards assumption checked via Schoenfeld residuals

Technical Difficulty: High ⚠️

This skill involves advanced statistical modeling. Results should be reviewed by a biostatistician, especially for:

• Proportional hazards assumption violations
• Small sample sizes (< 30 per group)
• Heavy censoring (> 50%)
• Time-varying covariates

References

See references/ folder for:

• Kaplan EL, Meier P (1958) original paper
• Cox DR (1972) regression models paper
• Sample datasets for testing
• Clinical reporting guidelines (ATN, CONSORT)

Parameters

Example

# Basic survival curve

# Example invocation: python scripts/main.py \
  --input clinical_data.csv \
  --time overall_survival_months \
  --event death \
  --group treatment_arm \
  --output ./results/ \
  --risk-table

Output includes:

• Survival curves with 95% confidence bands
• Median survival: Drug A = 28.4 months (95% CI: 24.1-32.7), Placebo = 18.2 months (95% CI: 15.3-21.1)
• Log-rank test p-value: 0.0023
• Hazard ratio: 0.62 (95% CI: 0.45-0.85), p = 0.003

Risk Assessment

Security Checklist

• No hardcoded credentials or API keys
• No unauthorized file system access (../)
• Output does not expose sensitive information
• Prompt injection protections in place
• Input file paths validated (no ../ traversal)
• Output directory restricted to workspace
• Script execution in sandboxed environment
• Error messages sanitized (no stack traces exposed)
• Dependencies audited

Prerequisites

# Python dependencies
pip install -r requirements.txt

Evaluation Criteria

Success Metrics

• Successfully executes main functionality
• Output meets quality standards
• Handles edge cases gracefully
• Performance is acceptable

Test Cases

1. Basic Functionality: Standard input → Expected output
2. Edge Case: Invalid input → Graceful error handling
3. Performance: Large dataset → Acceptable processing time

Lifecycle Status

• Current Stage: Draft
• Next Review Date: 2026-03-06
• Known Issues: None
• Planned Improvements:
  • Performance optimization
  • Additional feature support

Output Requirements

Every final response should make these items explicit when they are relevant:

• Objective or requested deliverable
• Inputs used and assumptions introduced
• Workflow or decision path
• Core result, recommendation, or artifact
• Constraints, risks, caveats, or validation needs
• Unresolved items and next-step checks

Error Handling

• If required inputs are missing, state exactly which fields are missing and request only the minimum additional information.
• If the task goes outside the documented scope, stop instead of guessing or silently widening the assignment.
• If scripts/main.py fails, report the failure point, summarize what still can be completed safely, and provide a manual fallback.
• Do not fabricate files, citations, data, search results, or execution outcomes.

Input Validation

This skill accepts requests that match the documented purpose of survival-analysis-km and include enough context to complete the workflow safely.

Do not continue the workflow when the request is out of scope, missing a critical input, or would require unsupported assumptions. Instead respond:

survival-analysis-km only handles its documented workflow. Please provide the missing required inputs or switch to a more suitable skill.

Response Template

Use the following fixed structure for non-trivial requests:

1. Objective
2. Inputs Received
3. Assumptions
4. Workflow
5. Deliverable
6. Risks and Limits
7. Next Checks

If the request is simple, you may compress the structure, but still keep assumptions and limits explicit when they affect correctness.

Inputs to Collect

• Required inputs: the user goal, the primary data or source file, and the requested output format.
• Optional inputs: output directory, formatting preferences, and validation constraints.
• If a required input is unavailable, return a short clarification request before continuing.

Output Contract

• Return a short summary, the main deliverables, and any assumptions that materially affect interpretation.
• If execution is partial, label what succeeded, what failed, and the next safe recovery step.
• Keep the final answer within the documented scope of the skill.

Validation and Safety Rules

• Validate identifiers, file paths, and user-provided parameters before execution.
• Do not fabricate results, metrics, citations, or downstream conclusions.
• Use safe fallback behavior when dependencies, credentials, or required inputs are missing.
• Surface any execution failure with a concise diagnosis and recovery path.