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tooluniverse-aging-senescence

Aging biology, cellular senescence, and longevity research. Covers senescence markers (p16/CDKN2A, SASP, SA-beta-gal), aging hallmarks, senolytic drug discovery (dasatinib+quercetin, fisetin, navitoclax), epigenetic clocks, telomere biology, and longevity GWAS. Use for senescence-pathway analysis, age-related disease genetics, senolytic-target discovery, and centenarian-genetics queries. Distinguishes correlative vs causal evidence (knockout, intervention).

64

Quality

75%

Does it follow best practices?

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SecuritybySnyk

Passed

No findings from the security scan

Fix and improve this skill with Tessl

tessl review fix ./plugin/skills/tooluniverse-aging-senescence/SKILL.md
SKILL.md
Quality
Evals
Security

Quality

Content

65%

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A highly actionable, well-structured research workflow with concrete tool calls and a clear phase sequence. Weaker on conciseness (explanatory reasoning) and progressive disclosure (monolithic single file with no references).

Suggestions

Tighten the 'Aging Research Reasoning' opening into a compact decision rule (cause vs consequence + evidence grade T1-T4) rather than an explanatory paragraph, trusting Claude's base knowledge.

Add explicit validation gates between phases (e.g. 'Classify hallmark and confirm causal vs correlative evidence before proceeding to drug discovery') to lift workflow clarity.

Move the detailed drug-candidate and pathway reference lists into a references/ file (e.g. DRUGS.md, PATHWAYS.md) and link them from the overview to introduce genuine progressive disclosure.

DimensionReasoningScore

Conciseness

The body is mostly efficient with high-value domain specifics, but the opening 'is this a cause or consequence of aging?' reasoning section is explanatory methodology that assumes less competence than warranted and could be tightened.

2 / 3

Actionability

Numerous copy-paste-ready executable calls with real parameters appear throughout (e.g. 'OpenGenes_get_gene(symbol="FOXO3")', 'KEGG_get_pathway_genes(pathway_id="hsa04218")', 'STRING_get_network(...)'), matching the 'fully executable, copy-paste ready' anchor.

3 / 3

Workflow Clarity

A clear 6-phase sequence with a diagram and a final report checklist is present, but validation checkpoints between phases (e.g. the evidence-grading gate) are implicit rather than framed as explicit pass/fail gates, so it does not reach the top anchor.

2 / 3

Progressive Disclosure

The skill is a well-sectioned single file but ~180 lines with no bundle files and no external references; content such as the drug-discovery or pathway detail that could live in separate references is inline, fitting the 'content that should be separate is inline' anchor.

2 / 3

Total

9

/

12

Passed

Description

85%

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, specific description that clearly states both capabilities and explicit use triggers within a distinct scientific niche. The only weakness is trigger phrasing that leans technical rather than natural.

DimensionReasoningScore

Specificity

Lists multiple concrete topics with specific named examples — 'senescence markers (p16/CDKN2A, SASP, SA-beta-gal)', 'senolytic drug discovery (dasatinib+quercetin, fisetin, navitoclax)', 'epigenetic clocks, telomere biology, and longevity GWAS' — matching the 'lists multiple specific concrete actions' anchor.

3 / 3

Completeness

Explicitly answers both what ('Covers senescence markers... longevity GWAS') and when ('Use for senescence-pathway analysis... centenarian-genetics queries') with an explicit trigger clause, matching the top anchor.

3 / 3

Trigger Term Quality

Relevant domain keywords are present via 'Use for senescence-pathway analysis, age-related disease genetics, senolytic-target discovery, and centenarian-genetics queries', but the hyphenated jargon constructions are not phrases a user would naturally say, so it falls short of the 'natural terms users would say' anchor.

2 / 3

Distinctiveness Conflict Risk

The cellular senescence / aging biology niche is clearly bounded and unlikely to trigger for unrelated skills, satisfying the 'clear niche with distinct triggers' anchor.

3 / 3

Total

11

/

12

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

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