Content
65%Weight 40%Scale 1-5Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.
The body is well-structured and assumes Claude's competence with concrete tool guidance, but it lacks explicit validation feedback loops for a clinical-call workflow and references four detail files that are not present in the bundle.
Suggestions
Add explicit validation/checkpoint steps in Phases 4-7 (e.g., 'if ClinGen returns no HI/TS score, fall back to OMIM inheritance as weaker evidence and re-score') to create a validate→fix→retry loop and lift workflow clarity above the batch-operation cap of 3.
Ship the referenced bundle files (CLASSIFICATION_GUIDE.md, ANALYSIS_PROCEDURES.md, REPORT_TEMPLATE.md, EXAMPLES.md) or inline their essential content so the one-level-deep references actually resolve.
De-duplicate the dosage-sensitivity reasoning between 'SV Pathogenicity Reasoning (Start Here)' and Phase 3, and collapse the Phase 5 overview with its detailed mapping, to tighten conciseness toward a 5.
| Dimension | Reasoning | Score |
|---|---|---|
Conciseness | Mostly efficient and trusts Claude's knowledge (e.g., 'The LLM knows the ACMG criteria codes and combination rules'), but dosage-sensitivity reasoning is repeated between the 'Start Here' section and Phase 3, and the Phase 5 scoring overview is restated in detail — minor trimming possible. | 4 / 5 |
Actionability | Concrete tool calls per phase with specific thresholds ('>=70% reciprocal overlap', 'ClinGen HI score 3', 'pLI >= 0.9', '>=1% frequency → BA1') and an explicit 0-10 score-to-tier mapping, but the actual implementation pseudocode is deferred to ANALYSIS_PROCEDURES.md, leaving a minor gap. | 4 / 5 |
Workflow Clarity | The 7-phase sequence is clearly laid out, but for a batch/clinical-call workflow there are no explicit validation checkpoints or validate→fix→retry feedback loops before the final classification, which per the rubric caps workflow clarity at 3. | 3 / 5 |
Progressive Disclosure | Structure is well organized with a 'Reference Files' section and one-level-deep pointers, but the referenced files (CLASSIFICATION_GUIDE.md, ANALYSIS_PROCEDURES.md, REPORT_TEMPLATE.md, EXAMPLES.md) are cited yet not present in the bundle, so navigation does not resolve. | 3 / 5 |
Total | 14 / 20 Passed |