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gtex-eqtl-skill

Fetch GTEx single-tissue eQTL associations from one variant input by accepting rsID, GRCh37, or GRCh38 input and resolving to the required GRCh38 query for the GTEx v2 API. Use when a user wants eQTL associations returned as JSON.

75

Quality

94%

Does it follow best practices?

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SecuritybySnyk

Low

Low-risk findings worth noting

SKILL.md
Quality
Evals
Security

Quality

Content

92%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A well-structured, highly actionable skill body: complete input/output contracts, an executable example command, and correct delegation of implementation to bundle scripts. The only improvement space is minor tightening of the multiple example blocks in the Input section.

Suggestions

Merge the grch37 and rsid example objects into a single code block (or bullets) to trim the Input section.

Reduce the four separator examples to one or two representative forms since the allowed-separator list already states the rule.

DimensionReasoningScore

Conciseness

The body is lean and spec-like: operating rules, input forms, output shapes, and an executable invocation, with no explanation of concepts Claude already knows. Minor trimming is possible — the two 'Other accepted object forms' JSON blocks could be merged, and the four separator examples could be cut to two — which matches anchor 4 rather than the every-token-earns-its-place anchor of 5.

4 / 5

Actionability

Fully executable guidance: a copy-paste-ready command ('echo '{"grch38":...}' | python scripts/gtex_eqtl.py'), concrete input schemas with real values, exact output shapes for success and failure, and the precise variantId format 'chr{chrom}_{pos}_{ref}_{alt}_b38'. It is not 4 because there are no gaps — the common invocation cases are all covered with real examples.

5 / 5

Workflow Clarity

This is a simple single-task skill where the entire workflow is delegated to one entry-point script, and the single action is unambiguous: pass JSON on stdin, get one JSON object on stdout. Per the simple-skill exception, a single unambiguous action scores 5; the operation is non-destructive and non-batch, so the validation cap does not apply.

5 / 5

Progressive Disclosure

The body is a concise interface document that points to the real entry-point 'scripts/gtex_eqtl.py', which exists in the bundle; the implementation (including scripts/variant_resolution.py, imported by the entry point) is appropriately split out of SKILL.md. Sections are well-organized and shallow with no nested references, so navigation is trivial. Not 4 because there is no misplaced or inline content that belongs in a separate file.

5 / 5

Total

19

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong description: concrete third-person actions, an explicit 'Use when' trigger, and a well-defined niche. The only gap is modest synonym coverage (e.g., 'SNP', spelled-out 'expression quantitative trait loci') for trigger-term breadth.

Suggestions

Add common synonyms users might say, e.g., 'SNP' or 'expression quantitative trait loci', to broaden natural trigger matching.

Consider extending the 'when' clause beyond JSON output desire, e.g., 'Use when a user asks about tissue-specific variant effects on gene expression.'

DimensionReasoningScore

Specificity

The description lists multiple concrete actions — 'Fetch GTEx single-tissue eQTL associations', 'accepting rsID, GRCh37, or GRCh38 input', 'resolving to the required GRCh38 query for the GTEx v2 API', 'returned as JSON' — with comprehensive coverage of the skill's inputs and output. It uses third person voice throughout, so no voice penalty applies.

5 / 5

Completeness

Both questions are explicitly answered: the 'what' (fetch single-tissue eQTL associations, resolve variant coordinates to GRCh38 for the GTEx v2 API) and the 'when' ('Use when a user wants eQTL associations returned as JSON'). This matches the anchor 5 example with a concrete trigger phrase; not 4 because the 'when' clause is explicit rather than merely adequate.

5 / 5

Trigger Term Quality

Good natural keyword coverage: 'GTEx', 'eQTL associations', 'rsID', 'GRCh37', 'GRCh38', 'variant', 'JSON' — exactly the terms a user needing this skill would say. A few natural synonyms are missing, such as 'SNP' and the spelled-out 'expression quantitative trait loci', which keeps it below the comprehensive-synonyms anchor of 5.

4 / 5

Distinctiveness Conflict Risk

GTEx/eQTL lookup is a clear niche with domain-specific triggers (GTEx, eQTL, rsID, GRCh38) that no general-purpose skill would claim, so conflict risk is minimal. It is not the 4 anchor because there is no meaningful overlap with a closely related skill.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository

openai/plugins

Path

plugins/life-science-research/skills/gtex-eqtl-skill/SKILL.md

Reviewed

Table of Contents

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