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ngs-dna-variant-calling

Dispatch WGS, WES, or targeted DNA variant requests to germline, somatic, or UMI-panel skills, then plan public nf-core/sarek, GATK4, DeepVariant, samtools, or bcftools workflows.

64

Quality

81%

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SecuritybySnyk

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SKILL.md
Quality
Evals
Security

Quality

Content

86%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A well-structured dispatcher skill: lean, fully executable commands, a clear input-then-dispatch-then-execute sequence, and clean section organization with no pedagogical padding. The only gaps are a missing error-recovery loop around the preflight/execution steps and minor wordiness in the Local Execution section.

DimensionReasoningScore

Conciseness

The body is lean and assumes competence — no explanations of what WGS or VCF is, and every section carries operational content. A few sentences edge toward over-explanation ('This package is suitable for focused local checks and run-envelope generation; subtype skills still own germline, somatic, UMI, reference-resource, cohort, annotation, and workflow assumptions'), which fits the 4 anchor 'efficient; minor instances that could be trimmed' rather than the every-token-earns-its-place 5.

4 / 5

Actionability

Fully executable, copy-paste-ready commands throughout: the preflight invocation with flags, the samtools/bcftools runner with concrete arguments (--sample-sheet, --region chr20:1-100000, --filter-min-qual 30), sample-sheet column requirements, and real nextflow/sarek run commands with genome and tools specified. Matches the 5 anchor.

5 / 5

Workflow Clarity

A clear sequence is present — confirm essential inputs, dispatch by sample model, preflight, local or kickoff execution — with the preflight script serving as a validation checkpoint and Guardrails as an error-avoidance checklist. It falls short of 5 because there is no explicit feedback loop (what to do when preflight or a run fails) and pair-metadata verification is mentioned but not proceduralized.

4 / 5

Progressive Disclosure

The skill bundle has no references/, scripts/, or assets/ directories, and the body is a well-organized dispatcher overview with clear sections (Essential Inputs, Dispatch, Public Default, Preflight, Local Execution, Kickoff, Guardrails). External script paths (plugins/ngs-analysis/scripts/...) are clearly signaled and one level deep, with no nested references — matching the clean-overview 5 anchor for a self-contained skill.

5 / 5

Total

18

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20

Passed

Description

66%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

The description is specific, tool-rich, and clearly delineates the dispatcher role with a distinct niche, but it omits any 'Use when...' trigger guidance, which caps completeness. Adding an explicit use-when clause and the literal phrase 'variant calling' would round it out.

Suggestions

Add a 'Use when...' clause, e.g. 'Use when the user asks for DNA variant calling, SNP/indel detection, or germline/somatic/UMI variant analysis from FASTQ, BAM, or CRAM data.'

Include the literal natural trigger phrase 'variant calling' and common synonyms such as 'whole genome sequencing', 'whole exome', and file extensions (.fastq, .bam, .vcf) users are likely to mention.

Briefly state the boundary in the description (e.g. 'dispatches to germline, somatic, or UMI-panel subtype skills rather than running the full pipeline itself') to further reduce overlap risk with those subtype skills.

DimensionReasoningScore

Specificity

Quotes concrete actions — 'Dispatch WGS, WES, or targeted DNA variant requests to germline, somatic, or UMI-panel skills, then plan public nf-core/sarek, GATK4, DeepVariant, samtools, or bcftools workflows' — naming specific subtypes, tools, and a workflow engine. It falls short of the 5 anchor because it covers only two core verbs (dispatch, plan) rather than a comprehensive list of specific actions, but is well above 3 since both actions are concrete and richly parameterized.

4 / 5

Completeness

The 'what' is explicit and clear (dispatch variant requests to subtype skills, then plan public workflows), but there is no 'Use when...' clause or equivalent trigger guidance, so per the judging guidelines completeness is capped at 3. It is not a 2 because the 'what' half is concrete and specific, not vague.

3 / 5

Trigger Term Quality

Natural user terms are present: 'WGS', 'WES', 'targeted DNA', 'germline', 'somatic', 'UMI-panel' — exactly what a genomics user would say. A few natural variants are missing (the literal phrase 'variant calling', 'whole genome/exome sequencing', input file extensions like .bam/.fastq), so it fits the 4 anchor ('good keyword coverage; a few natural terms missing') rather than 5, and is clearly better than the partial coverage of 3.

4 / 5

Distinctiveness Conflict Risk

It carves out a clear niche — a DNA variant-calling dispatcher for WGS/WES/panel data — with distinct triggers. The only overlap risk is with the three subtype skills it names (ngs-dna-germline-variants, etc.), which is intentional hand-off behavior, matching the 4 anchor 'mostly distinct; minor overlap risk with closely related skills' rather than the minimal-conflict 5.

4 / 5

Total

15

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository

openai/plugins

Path

plugins/ngs-analysis/skills/ngs-dna-variant-calling/SKILL.md

Reviewed

Table of Contents

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