Analyze a product walkthrough, bug report video, Loom, or ScreenPal using Minutes transcription plus visual review. Use when the user wants a recorded demo or bug clip turned into a durable brief with transcript, key frames, issues, and next steps.

Analyze a product walkthrough, bug report video, Loom, or ScreenPal using Minutes transcription plus visual review. Use when the user wants a recorded demo or bug clip turned into a durable brief with transcript, key frames, issues, and next steps.

Create and configure embedded playgrounds using createPlayground(), EmbedOptions, container setup, loading modes (eager/lazy/click), and appUrl for self-hosted instances. Load this skill when embedding LiveCodes in web pages, configuring playground containers, or setting up SDK integration.

Use when styling any tool/block button, palette tile, icon chip, or new clickable square in Tiny World Builder. The locked-in "block" aesthetic — a raised square with a dark category-colored outline, an inner white line, and a white-bodied glyph outlined in the same dark color. Apply this whenever a new icon button/tile is added so the UI stays consistent.

Group related tickers into investment themes — AI infra, HK dividend, EV supply chain, biotech catalysts — with theme-level AI summary and news keyword monitoring. Each theme is a named bag of tickers plus keywords the system watches for you. Use when: creating a themed basket, pulling up a theme's aggregated view, adding/removing tickers, monitoring news around a topic. Triggers on: "create an AI infra theme", "show my themes", "add MSFT to AI theme", "what's happening in HK dividend", "主题研究", "AI基建", "港股高息", "投资主题".

Integrates prediction market data (Polymarket) with options analysis to surface mispricing signals between event probabilities and options-implied probabilities. Triggers: "polymarket signals", "prediction market vs options", "event probability", "rate cut odds", "election odds vs options", "polymarket arbitrage", "implied probability mismatch", "prediction market data", "event-driven options"

Duan-Yongping-style seller playbook for any ticker: Sell Put at your "willing buy" price, Covered Call for yield enhancement, and a Panic-Buy context read off current VIX. The response is three tightly-scoped analysis cards — not a generic options screener — derived from the specific framework that made Duan Yongping famous in Chinese retail investing (seller-only, rent-collection logic, never a buyer of options). Triggers: "Duan Yongping style AAPL", "sell put NVDA willing to buy at 120", "covered call yield TSLA", "should I sell AAPL put here", "seller strategy MSFT", "Duan-style analysis", "premium collection setup", "nationalist seller playbook"

Serenity-style "Chokepoint Theory" applied to AI supply chains. Identifies physically irreplaceable bottleneck suppliers — small-cap near-monopolies buried 4–7 layers deep — whose capacity constraints force violent repricing when demand outgrows supply. Uses a 5-factor scoring model (Concentration, Irreplaceability, Qualification Gate, Discovery Gap, Demand Tension) to screen and rank candidates. This is AlphaGBM's independent reading of Serenity (@aleabitoreddit)'s publicly shared methodology — NOT affiliated with or endorsed by Serenity. Triggers: "chokepoint analysis", "AI supply chain bottleneck", "find the shiso leaf", "Serenity-style screen", "which small-caps own the bottleneck", "InP substrate play", "co-packaged optics chokepoint", "irreplaceable supplier in AI buildout", "supply chain concentration risk"

AI DevKit · Review and improve documentation for novice users. Use when users ask to review docs, improve documentation, audit README files, evaluate API docs, review guides, or improve technical writing.

AI DevKit · Orchestrator for structured SDLC phase skills. Use when the user wants to run the full lifecycle or choose the next phase across requirements, design, planning, implementation, testing, and review.

Build, repair, or review Maple dashboard widgets via the MCP. Triggers on phrases like 'create_dashboard', 'add_dashboard_widget', 'update_dashboard_widget', 'dashboard widget JSON', 'panel_type', 'QueryDraft', or any session that submits widget JSON to the maple MCP. Covers the panel-type table, the kind-discriminated data source, the percent vs percent_100 unit rule, valid aggregations and group-by tokens per source, the custom whereClause grammar, the scalar reduceToValue transform, and the verification step (MCP success != chart correctness).

Tinybird TypeScript SDK for defining datasources, pipes, and queries with full type inference. Use when working with @tinybirdco/sdk, TypeScript Tinybird projects, or type-safe data ingestion and queries.

Computational vaccine candidate design: peptide/subunit vaccines via MHC-I/MHC-II epitope prediction (IEDB), population HLA coverage optimization, B-cell epitope identification, and cross-strain conservation analysis. Use for vaccine epitope prediction, HLA allele coverage, multi-epitope construct design, and immunogenicity assessment. Combines predicted MHC binding with experimentally validated IEDB epitopes for higher-confidence designs.

Interpret a missense variant via ESMC-6B Sparse Autoencoder (SAE) feature activations. For a given protein + variant, computes which interpretable SAE features (catalytic, ligand-binding, PTM, structural motif, domain, etc.) are lost or gained at the mutation site. Use when standard pathogenicity scores (AlphaMissense, ClinVar) say a variant is damaging but you need a MECHANISTIC explanation — e.g. 'why is this variant LoF?' Complements (does not replace) variant-interpretation and variant-to-mechanism skills, which focus on ACMG classification or regulatory mechanism.

Population genetics analysis — allele frequencies (gnomAD, 1000 Genomes), Hardy-Weinberg equilibrium testing, Fst between populations, GWAS associations, evolutionary constraint scores. Use for cross-population variant comparison, ancestry-aware allele frequency lookups, and population-level evolutionary analysis.

Pharmacogenomics (PGx) research — drug-gene interactions (CPIC, PharmGKB), CPIC dosing guidelines, variant-drug-response associations, ethnic-allele-frequency considerations, and metabolizer-status scoring. Use for PGx-informed dosing recommendations, CYP/HLA pharmacogenomic allele interpretation, and clinically-actionable PGx report generation.

Microbiome and metagenomics analysis using MGnify, GTDB taxonomy, ENA sequencing data, and EuropePMC literature. Covers taxonomic classification, genome quality assessment, biome-clinical phenotype linkage, and pathway interpretation. Use for amplicon/shotgun metagenomics study analysis.

Predict patient response to immune checkpoint inhibitors (ICIs) by integrating tumor mutational burden (TMB), microsatellite instability (MSI), PD-L1 expression, HLA status, and immune-related gene expression. Outputs ICI Response Score with drug-specific recommendations and resistance-risk assessment. Use for melanoma/NSCLC/RCC immunotherapy decision support.

Immunology research workflows: antibody-antigen interactions, T/B cell repertoire, MHC/HLA binding prediction, autoimmune disease genetics, vaccine epitope mapping. Uses IEDB, IMGT, SAbDab, UniProt. Use for adaptive immunity questions, immune response analysis, antibody/TCR/BCR characterization, immunogenicity prediction, and immune-pathway-to-disease mapping.

Histone-modification ChIP-seq, ATAC-seq accessibility, chromatin state, and TF binding analysis from ENCODE, Roadmap Epigenomics, ChIP-Atlas. Use for chromatin-state-by-tissue queries, TF-binding-by-region, regulatory landscape mapping, and ENCODE-cCRE annotations. For DNA methylation use tooluniverse-epigenomics; for RNA-seq use tooluniverse-rnaseq-deseq2.