Analyze a single FASTA file (nucleotide or protein), compute sequence-level metrics (GC, ORFs, MW, pI, GRAVY, secondary-structure fractions) with Biopython, and write a Markdown report plus structured JSON for downstream chaining.

Unified analysis pipeline for affinity-based proteomics platforms — Olink (PEA, NPX) and SomaLogic SomaScan (SOMAmer, RFU). Platform-aware QC, normalisation, differential abundance, volcano plots, heatmaps, and PCA.

Create a reusable SkillPack from a successful completed task. Use when the user wants to convert a one-off research, coding, analysis, or content workflow into a distributable local SkillPack with `skillpack.json`, local skills under `skills/`, starter prompts, start scripts, and an optional zip package.

Design, improve, and evaluate reusable agent skills with high-quality SKILL.md files, precise trigger descriptions, progressive disclosure, and testable behavior. This skill should be used when users ask to create a new skill, rewrite or review an existing skill, audit a skill collection such as `config/source/skills` for redundancy or overlap, improve skill trigger quality, organize skill references, or evaluate whether a skill should trigger and behave correctly.

Use when running or scheduling periodic repository review cycles that must dispatch the correct reviewer, aggregate findings, and escalate outcomes into reports, issues, or corrective PRs across API contracts, documentation freshness, code quality, and CloudBase skill quality.

Periodically analyze open pull requests for CI failures, code review feedback, and quality issues, then fix them in batch. Use this skill when the user asks to check PR status, triage CI failures, fix review comments, analyze open PRs, or run a scheduled PR health check across the repository.

Spec and no-spec planning workflows derived from local slash commands (requirements, design, tasks).

Triage, repair, and close MCP attribution issues from the local report API with evidence-driven decisions and isolated Worktrunk worktrees. Use this skill when Codex needs to process `tool` attribution issues and skills-related attribution issues, inspect related runs, decide whether the issue is actionable in `mcp/src` or `config/source/skills`, update attribution fields as `owner=codex`, and then complete the fix loop through GitHub issue tracking, worktree-based code changes, PR submission, and follow-up iteration when the problem is repairable.

Analyze, standardize, validate, and sync locally maintained skills into agent skill directories with a `skills` CLI-aligned workflow. Use this skill when Codex needs to turn ad-hoc prompt or rules folders into reusable `SKILL.md`-based skills, install or sync one or more local skills from `./skills` into Claude, Cursor, CodeBuddy, Codex, or similar agent directories, or manage local skill path mappings and symlink or copy installation behavior.

Reusable git delivery workflows derived from local slash commands (commit, push, PR, release notes, and GitHub Actions failure triage with worktree-based fixes).

Documentation and extension workflows derived from local slash commands (docs, explanation, issues, prototypes, tutorials, MCP design review).

Use when auditing repository documentation for drift, stale statements, broken references, or README mismatches, especially across published docs under `doc/` and key entry surfaces such as `README.md` (English default), `README.zh-CN.md`, `mcp/README.md`, and `mcp/README.zh-CN.md` during periodic maintenance or before preparing corrective PRs.

Perform a full codebase review, categorize findings by severity, file GitHub issues, then fix each issue in an isolated git worktree and submit PRs. Use this skill when the user asks to audit the codebase, do a comprehensive code review, find and fix security/quality/reliability issues, or run a proactive health check across the entire repository.

Use when auditing CloudBase cloud API wrappers, MCP tools, generated action metadata, or related docs for outdated or incorrect action names, parameters, casing, request shapes, or missing contract tests, especially during periodic quality review or before preparing corrective PRs.

Essential CloudBase (TCB, Tencent CloudBase, 云开发, 微信云开发) development guidelines. MUST read for CloudBase Web apps, mini programs, backend services, cloud functions, MySQL/NoSQL/PostgreSQL, auth, storage, CloudRun, or AI/LLM work. Do NOT use for non-Tencent-Cloud / non-CloudBase projects, pure frontend with no CloudBase backend, or self-hosted backends with no CloudBase dependency.

Use when users need to implement, integrate, debug, build, deploy, or validate a Web frontend after the product direction is already clear, especially for React, Vue, Vite, browser flows, or CloudBase Web integration.

Use when users need visual direction, interface hierarchy, layout decisions, design specifications, or prototypes before implementing a Web or mini program UI.

Use when medium-to-large changes need explicit requirements, technical design, and task planning before implementation, especially for multi-module work, unclear acceptance criteria, or architecture-heavy requests.

[Deprecated] Use when building frontend Web apps that talk to CloudBase Relational Database via @cloudbase/js-sdk – provides the canonical init pattern so you can then use Supabase-style queries from the browser. New environments should use PostgreSQL with app.rdb() — see postgresql-development skill instead.

[Deprecated] This is the required documentation for agents operating on the CloudBase Relational Database through MCP. It defines the canonical SQL management flow with `queryMysqlDatabase`, `manageMysqlDatabase`, `queryPermissions`, and `managePermissions`, including MySQL provisioning, destroy flow, async status checks, safe query execution, schema initialization, and permission updates. New environments should use PostgreSQL — see postgresql-development skill instead.