Visualize, analyze, and render protein and molecular structures using PyMOL. Use when the user wants to create images of protein structures, perform structural alignments or superposition, measure distances or contacts, highlight binding sites or active site residues, color by B-factor/pLDDT, or analyze protein-ligand interactions. Do not use for docking, molecular dynamics, or sequence-only analysis.

Query PubChem, search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminformatics. Use when a user asks about a specific chemical, drug, or molecule.

Searches for homologous protein sequences using MMseqs2 (fast, default) or BLAST (comprehensive, fallback). Trigger this whenever the user provides a protein sequence or FASTA file and asks to find homologues, sequence matches, or wants to infer protein function based on sequence similarity, but not when the user wants to infer protein function based on structural similarity.

Query the OpenAlex scholarly database for research papers, authors, institutions, topics, sources, publishers, funders, geo-locations, and keywords. Use when searching academic papers, resolving DOIs, downloading open-access PDFs, finding an author's publications, aggregating bibliometric data (citation counts, h-index, impact factor), exploring the research taxonomies, or performing DOI lookups.

Create a slash-command `/goal` for long-running Codex or Claude Code work when the user explicitly asks for a `/goal`, agent goal, or completion condition. Outputs one goal line with the objective, starting context, validation evidence, and stop condition.

Imperative guidance for the System.Text.Json APIs added in .NET 11: the built-in `JsonNamingPolicy.PascalCase` naming policy, and the strongly-typed `JsonSerializerOptions.GetTypeInfo<T>()` and `JsonSerializerOptions.TryGetTypeInfo<T>(out JsonTypeInfo<T>? info)` metadata accessors. USE FOR: serializing or deserializing JSON in a net11.0-or-later project when you need PascalCase JSON property names without writing a custom naming policy, a strongly-typed `JsonTypeInfo<T>` instead of the non-generic `JsonTypeInfo`, or a no-throw way to probe whether a type's serialization metadata is resolved. DO NOT USE FOR: projects targeting net10.0 or earlier (none of these APIs exist there), JSON libraries other than System.Text.Json (e.g. Newtonsoft.Json), or camelCase / snake_case / kebab-case naming — those policies shipped in earlier releases.

Migrate a .NET 8 project to .NET 9 and resolve all breaking changes. USE FOR: upgrading TargetFramework from net8.0 to net9.0, fixing build errors after updating the .NET 9 SDK, resolving behavioral changes in .NET 9 / C# 13 / ASP.NET Core 9 / EF Core 9, replacing BinaryFormatter (now always throws), resolving SYSLIB0054-SYSLIB0057, adapting to params span overload resolution, fixing C# 13 compiler changes, updating HttpClientFactory for SocketsHttpHandler, and resolving EF Core 9 migration/Cosmos DB changes. DO NOT USE FOR: .NET Framework migrations, upgrading from .NET 7 or earlier, greenfield .NET 9 projects, or cosmetic modernization unrelated to the upgrade.

Migrate a .NET 10 project or solution to .NET 11 and resolve all breaking changes. This is a MIGRATION skill — use it when upgrading from .NET 10 to .NET 11, NOT for writing new programs. USE FOR: upgrading TargetFramework from net10.0 to net11.0, fixing build errors after updating the .NET 11 SDK, resolving source-breaking and behavioral changes in .NET 11 runtime, C# 15 compiler, and EF Core 11, adapting to updated minimum hardware requirements (x86-64-v2, Arm64 LSE), and updating CI/CD pipelines and Dockerfiles for .NET 11. DO NOT USE FOR: .NET Framework migrations, upgrading from .NET 9 or earlier, greenfield .NET 11 projects, or cosmetic modernization unrelated to the upgrade. NOTE: .NET 11 is in preview. Covers breaking changes through Preview 3.

Analyzes test suites in any language and tags each test with standardized traits (positive, negative, critical-path, boundary, smoke, regression, integration, performance, security). Use when the user wants to categorize, audit, or label tests with traits. Works across .NET (MSTest/xUnit/NUnit/TUnit), Python (pytest), TS/JS (Jest/Vitest), Java, Go, Ruby, Rust, Swift, Kotlin, PowerShell, and C++ — auto-editing when the framework has canonical tag syntax, otherwise report-only. Do not use for writing new tests, running tests, or migrating frameworks.

Web search via Tavily API (alternative to Brave). Use when the user asks to search the web / look up sources / find links and Brave web_search is unavailable or undesired. Returns a small set of relevant results (title, url, snippet) and can optionally include short answer summaries.

Suggests using Microsoft Testing Platform (MTP) hot reload to iterate fixes on failing tests without rebuilding. Use when user says "hot reload tests", "iterate on test fix", "run tests without rebuilding", "speed up test loop", "fix test faster", or needs to set up MTP hot reload to rapidly iterate on test failures. Covers setup (NuGet package, environment variable, launchSettings.json) and the iterative workflow for fixing tests. DO NOT USE FOR: writing test code, diagnosing test failures, running tests normally with dotnet test (use run-tests), applying test filters, producing TRX reports, CI/CD pipeline configuration, or Visual Studio Test Explorer hot reload (which is a different feature).

How to handle `GRIDA-SEC-<id>` security boundaries in the Grida repo. Triggers when you encounter a `GRIDA-SEC` tag in source/docs, when modifying files under any tagged path, or when adding a new prevented- vulnerability record. Each `GRIDA-SEC-<id>` identifies a structural trust boundary documented in `/SECURITY.md`. This skill explains the contract, mandates a security review before committing changes to any tagged file, and shows how to register a new id. Use whenever "GRIDA-SEC" appears in context.

Guides work on the Figma I/O package (@grida/io-figma, packages/grida-canvas-io-figma/). Covers the fig-kiwi binary parser, Kiwi→REST→Grida conversion pipeline, fig2grida CLI, REST API JSON conversion, and testing with clipboard/fig/REST fixtures. Use when adding node type support, fixing conversion bugs, extending fig2grida, working on the fig-kiwi parser, writing tests for Figma import, or debugging clipboard paste failures after a Figma update.

Author and manage user-facing documentation for the Grida Canvas editor. Covers writing style, tone, product screenshots, demo state preparation, and content structure for pages under docs/editor/. Use when creating or editing canvas editor documentation, capturing screenshots of canvas features, or planning visual demos. Trigger phrases: "write user docs", "document this feature", "screenshot for docs", "canvas user guide", "update help page".

Use BEFORE editing any file in `supabase/migrations/` or `supabase/schemas/`, OR when the user runs a `/database` subcommand (`compact local migration`, `rls scenarios`, `align`). Encodes the three contracts that protect the Grida database layer: applied migrations are immutable, RLS implementation mirrors tests (never the reverse), `schemas/*.sql` is the human-readable end-state. Companion to `supabase/AGENTS.md` (RLS, grants, security boundaries).

Research, compare, and update AI model configurations. Covers text model tiers, image and video generation models, image tool models, pricing data sourcing, and provider-cost metering against prepaid org credit. Use when bumping model versions, adding new models, updating pricing, or auditing model specs against provider documentation.

This skill should be used when code search is needed (whether explicitly requested or as part of completing a task), when indexing the codebase after changes, or when the user asks about ccc, cocoindex-code, or the codebase index. Trigger phrases include 'search the codebase', 'find code related to', 'update the index', 'ccc', 'cocoindex-code'.

This skill should be used when the user asks to "create an MCP App", "add a UI to an MCP tool", "build an interactive MCP View", "scaffold an MCP App", or needs guidance on MCP Apps SDK patterns, UI-resource registration, MCP App lifecycle, or host integration. Provides comprehensive guidance for building MCP Apps with interactive UIs.

Scan C# source files for hard-to-test static dependencies — DateTime.Now/UtcNow, File.*, Directory.*, Environment.*, HttpClient, Console.*, Process.*, and other untestable statics. Produces a ranked report of static call sites by frequency. USE FOR: find untestable statics, scan for static dependencies, testability audit, identify hard-to-mock code, find DateTime.Now usage, detect static coupling, testability report, static analysis for testability. DO NOT USE FOR: generating wrappers (use generate-testability-wrappers), migrating code (use migrate-static-to-wrapper), general code review, or finding statics that are already behind abstractions.

Manage durable working-session memory for coding agents. Use when a user asks to preserve or recover agent context across disconnects, VS Code restarts, long-running work, handoffs, or any session where important state should be written periodically under the repo's session directory. Do NOT use for: simple questions, short tasks, one-off commands, linting, or code review.