Model interpretability and explainability using SHAP (SHapley Additive exPlanations). Feature importance, dependence plots, interaction effects, and fairness analysis for any black-box model.

A skill for performing sequence alignment using NCBI BLAST API. Supports nucleotide and protein sequence comparison against major biological databases.

Use when designing or revising a company's commercial policy — the rules of engagement governing discounts off list price, approver thresholds, exception flows, and the deal framework that Deal Desk and AEs operate under. Covers discount matrix design (ARR band x term length x payment terms x strategic value), commercial policy design, exception policy, discount governance, approval thresholds, deal framework structure, and policy linting (contradictions, gaps, cliff edges, gaming surfaces). For Head of Commercial, Head of Deal Desk, VP Sales, or RevOps at the policy-design moment — NOT per-deal application (that is deal-desk) and NOT pricing model selection (that is pricing-strategist).

Statistical visualization library integrated with pandas; use it when you need fast EDA of distributions, relationships, and categorical comparisons (e.g., box/violin/pair plots and heatmaps) with strong default aesthetics on top of matplotlib.

Use when building a quarterly bookings forecast, ARR projection, pipeline forecast, NRR projection, or commit/best-case/pipe-only board number — especially when the CRO needs to walk the board through funnel math + cohort ARR + per-stage conversion assumptions without the theatre of a single undefended number. Decomposes pipeline into commit, best-case, and pipe-only tiers; projects cohort-level NRR/GRR to surface leaky cohorts before they show up in the consolidated number; scores per-stage funnel confidence so soft-floor stages get treated differently from high-confidence ones. Every output explicitly names the conversion rate used, the data window, and the weighting choice. For Head of Commercial, RevOps, VP Sales, and CRO at quarterly forecast or board prep. NOT financial close (see finance/financial-analysis). NOT strategic CRO hiring/territory (see c-level-advisor/cro-advisor). NOT pricing (see sibling pricing-strategist).

Use when reviewing or rebalancing direct vs. partner-led channel economics — computing fully-loaded cost-to-serve per channel, channel ROI with cash / LTV / marginal lenses, and optimal channel mix subject to constraints. For Head of Commercial, RevOps, and VP Sales doing quarterly channel review when pipeline is mixed (e.g., 60% direct + 40% partner-led) and nobody actually knows which channel makes money after CAC, support load, partner discount, deal-velocity differences, retention differential, and overhead allocation are all loaded in. Outputs cost to serve, channel ROI verdicts (DOUBLE-DOWN / MAINTAIN / DEFUND / EXIT), a sensitivity-tested channel-mix recommendation, and the diminishing-returns inflection (e.g., 'which channel actually makes money — direct or partner?').

/cs:vpe-review <plan> — Throughput-first VP of Engineering interrogation of any plan that touches delivery, eng hiring, team structure, or production discipline. Use when cycle time balloons, DORA metrics slide, or before committing to an eng hiring wave or a reorg.

/cs:post-mortem <decision> — Honest retrospective on an executed decision, scored against original assumptions and dissent. Closes the strategic sprint loop. Use when a decision hits its 90-day review checkpoint or its kill criteria trigger — e.g. scoring last quarter's pricing change against its pre-committed success metrics.

Deep generative models for single-cell omics; use when you need probabilistic batch correction (scVI), transfer learning, uncertainty-aware differential expression, or multimodal integration (totalVI/MultiVI).

/cs:onboard — Founder interview that populates ~/.claude/company-context.md using the canonical 7-dimension cs-onboard schema. The first command to run when starting with c-level-agents. Use when setting up the virtual C-suite for a new company, or when advisors lack company context — e.g. before a first /cs:boardroom or after a fundraise changes the numbers.

/cs:office-hours <topic> — YC-style 6-question founder interrogation before any advice. Forces clarity on problem, customer, distribution, defensibility, capital, and founder fit. Use when a founder question is too vague to route — e.g. 'should we grow faster?' — or before drafting a strategy brief.

Auto-annotate cell clusters from single-cell RNA data using marker genes.

/cs:gc-review <plan> — General Counsel interrogation of contracts, IP, regulatory, term sheets, and employment-law surface. Use when reviewing a term sheet before signing, redlining a customer MSA, or checking IP assignment and regulatory exposure on a new product.

/cs:freeze <decision> <days> — Lock a strategic decision for a cooldown period to prevent impulse reversal. Mirrors gstack's safety primitives for the business layer. Use when an irreversible decision was made under pressure — e.g. a layoff plan or multi-year contract — and deserves a cooling-off lock before execution.

/cs:founder-mode <question> — Auto-routes any founder question to the right C-role advisor or to /cs:boardroom for multi-role topics. The single-command entry point. Use when a founder asks any strategic question without knowing which advisor or command fits — e.g. 'runway pressure' routes to the CFO, 'gross retention dropped' routes to the CCO.

A comprehensive toolkit for survival analysis and time-to-event modeling in Python using scikit-survival; use it when you need to model censored time-to-event outcomes, fit Cox/RSF/GB models or Survival SVMs, evaluate with C-index/Brier score, or handle competing risks.

/cs:execute <decision> — Generate a 90-day execution plan with weekly milestones, DRIs, and check-in cadence from an approved decision. Use when a logged decision needs to become an operating plan — e.g. turning an approved market-entry call into weekly milestones with DRIs.

/cs:decide <memo> — Log a decision to two-layer memory via decision-logger. Approved memo becomes durable; raw transcripts kept for reference. Use when the founder has approved a boardroom memo and the decision must become durable company memory — e.g. right after /cs:boardroom concludes.

/cs:cto-review <plan> — Architecture and scaling interrogation. Tech debt, scaling cliffs, team scaling, build-vs-buy. Use when committing to an architecture, planning for 10x load, or weighing a rebuild against a vendor.

A Python bioinformatics toolkit for sequence, phylogeny, and microbiome/community-ecology analysis; use it when you need to compute diversity/ordination/statistics from biological data and standard formats (FASTA/FASTQ/Newick/BIOM).