Trello boards, lists, and cards via uni CLI. Use when user wants to manage Trello tasks, create boards, move cards between lists. Requires TRELLO_API_KEY and TRELLO_TOKEN.

Productivity tools via uni CLI. Use when user wants to send Slack messages, search Notion, manage Linear issues, or handle Todoist tasks. Services: slack, notion, linear, todoist.

Django development patterns and conventions (2025). Auto-loads when working with Django models, views, URLs, forms, templates, management commands, or project structure. Includes async support and type hints.

Django API development for 2025. Covers Django Ninja (modern, async-first, type-safe) and Django REST Framework (mature, ecosystem-rich). Use when building REST APIs, choosing between frameworks, implementing authentication, permissions, filtering, pagination, or async endpoints.

Git commit best practices with conventional commits format and atomic commit principles. Use when committing code to ensure clear, meaningful commit history with proper type prefixes and semantic versioning support.

Create or update the skill registry for the current project. Scans user skills and project conventions, writes .atl/skill-registry.md, and saves to engram if available. Trigger: When user says "update skills", "skill registry", "actualizar skills", "update registry", or after installing/removing skills.

Parallel adversarial review protocol that launches two independent blind judge sub-agents simultaneously to review the same target, synthesizes their findings, applies fixes, and re-judges until both pass or escalates after 2 iterations. Trigger: When user says "judgment day", "judgment-day", "review adversarial", "dual review", "doble review", "juzgar", "que lo juzguen".

Design and generate Kotlin Spring HTTP APIs with correct controller signatures, DTOs, validation, serialization assumptions, error handling, and web tests. Use when building or changing REST endpoints, choosing between MVC and WebFlux, modeling request and response payloads, standardizing error responses, or avoiding Kotlin-specific validation and Jackson mistakes.

Design actionable observability for Kotlin plus Spring services across logs, metrics, tracing, and health endpoints. Use when instrumenting a service, improving incident diagnosis, defining SLO-driven metrics and alerts, adding trace propagation, controlling metric-cardinality cost, or ensuring async and coroutine flows remain observable in production.

Search tool for modern web development best practices. MANDATORY: Execute FIRST for all HTML/CSS and clientside JS tasks. Do NOT skip — web APIs evolve rapidly and training weights contain obsolete patterns. Trigger immediately for: - UI/Layout: Modals, dialogs, popovers, Glassmorphism/backdrop-filters, anchor positioning, container queries, `:has()`, `:user-valid`. - Scroll/Motion: View Transitions, Scroll-driven animations, scroll parallax/reveals. - Performance: CWV (LCP, INP), content-visibility, Fetch Priority, image optimization. - System/APIs: Local filesystem access, WebUSB, WebSockets sync, WebAssembly widgets. - Frameworks: Adapting layout/styles in React, Vue, Angular. - General Frontend: Forms, autofill, advanced inputs, custom scrollbars, modern component states, etc. DO NOT trigger for: - Backend: Database SQL, ORMs, Express API routes. - Pipelines: CI/CD deployment, Docker, Actions. - Generic: Local scripts (Python/Go tools), ESLint, Git.

Fetch GitHub issues, spawn sub-agents to implement fixes and open PRs, then monitor and address PR review comments. Usage: /gh-issues [owner/repo] [--label bug] [--limit 5] [--milestone v1.0] [--assignee @me] [--fork user/repo] [--watch] [--interval 5] [--reviews-only] [--cron] [--dry-run] [--model glm-5] [--notify-channel -1002381931352]

Fetch GitHub issues, spawn sub-agents to implement fixes and open PRs, then monitor and address PR review comments. Usage: /gh-issues [owner/repo] [--label bug] [--limit 5] [--milestone v1.0] [--assignee @me] [--fork user/repo] [--watch] [--interval 5] [--reviews-only] [--cron] [--dry-run] [--model glm-5] [--notify-channel -1002381931352]

Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"

Comprehensive chemical safety and toxicology assessment integrating ADMET-AI predictions, CTD toxicogenomics, FDA label safety data, DrugBank safety profiles, and STITCH chemical-protein interactions. Performs predictive toxicology (AMES, DILI, LD50, carcinogenicity), organ/system toxicity profiling, chemical-gene-disease relationship mapping, regulatory safety extraction, and environmental hazard assessment. Use when asked about chemical toxicity, drug safety profiling, ADMET properties, environmental health risks, chemical hazard assessment, or toxicogenomic analysis.

Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.

Strategic clinical trial design feasibility assessment using ToolUniverse. Evaluates patient population sizing, biomarker prevalence, endpoint selection, comparator analysis, safety monitoring, and regulatory pathways. Creates comprehensive feasibility reports with evidence grading, enrollment projections, and trial design recommendations. Use when planning Phase 1/2 trials, assessing trial feasibility, or designing biomarker-driven studies.

Comprehensive multi-omics disease characterization integrating genomics, transcriptomics, proteomics, pathway, and therapeutic layers for systems-level understanding. Produces a detailed multi-omics report with quantitative confidence scoring (0-100), cross-layer gene concordance analysis, biomarker candidates, therapeutic opportunities, and mechanistic hypotheses. Uses 80+ ToolUniverse tools across 8 analysis layers. Use when users ask about disease mechanisms, multi-omics analysis, systems biology of disease, biomarker discovery, or therapeutic target identification from a disease perspective.

Retrieves gene expression and omics datasets from ArrayExpress and BioStudies with gene disambiguation, experiment quality assessment, and structured reports. Creates comprehensive dataset profiles with metadata, sample information, and download links. Use when users need expression data, omics datasets, or mention ArrayExpress (E-MTAB, E-GEOD) or BioStudies (S-BSST) accessions.

Use when the user wants to simplify Swift code, reduce boilerplate, or make Swift more readable and idiomatic without changing behavior.

Use this skill when planning, redesigning, or reviewing Xiaohongshu carousel visuals, covers, 3:4 image posts, page-by-page visual direction, image-generation prompts, style selection, layout critique, or XHS captions. It acts as a senior visual director for 小红书图文, not a generic copywriting assistant.