Deep generative models for single-cell omics. Use when you need probabilistic batch correction (scVI), transfer learning, differential expression with uncertainty, or multi-modal integration (TOTALVI, MultiVI). Best for advanced modeling, batch effects, multimodal data. For standard analysis pipelines use scanpy.

Run shellcheck and actionlint on shell scripts and GitHub Actions workflows. Use before pushing or when fixing lint issues.

Designs incremental migration strategies, identifies service boundaries, produces dependency maps and migration roadmaps, and generates API facade designs for aging codebases. Use when modernizing legacy systems, implementing strangler fig pattern or branch by abstraction, decomposing monoliths, upgrading frameworks or languages, or reducing technical debt without disrupting business operations.

Provides idiomatic Kotlin implementation patterns including coroutine concurrency, Flow stream handling, multiplatform architecture, Compose UI construction, Ktor server setup, and type-safe DSL design. Use when building Kotlin applications requiring coroutines, multiplatform development, or Android with Compose. Invoke for Flow API, KMP projects, Ktor servers, DSL design, sealed classes, suspend function, Android Kotlin, Kotlin Multiplatform.

Optimize cloud costs across AWS, Azure, GCP, and OCI through resource rightsizing, tagging strategies, reserved instances, and spending analysis. Use when reducing cloud expenses, analyzing infrastructure costs, or implementing cost governance policies.

This skill enables Claude to manage isolated test environments using Docker Compose, Testcontainers, and environment variables. It is used to create consistent, reproducible testing environments for software projects. Claude should use this skill when the user needs to set up a test environment with specific configurations, manage Docker Compose files for test infrastructure, set up programmatic container management with Testcontainers, manage environment variables for tests, or ensure cleanup after tests. Trigger terms include "test environment", "docker compose", "testcontainers", "environment variables", "isolated environment", "env-setup", and "test setup".

Use when writing blog posts or documentation markdown files - provides writing style guide (active voice, present tense), content structure patterns, and MDC component usage. Overrides brevity rules for proper grammar. Use nuxt-content for MDC syntax, nuxt-ui for component props.

Use this skill when the user asks to review a DuckDuckGo Android public API proposal. If given an Asana task URL, first fetch the task and confirm it is an API proposal before invoking — do not invoke just because a URL was paired with "review". Confirmed signals: the task title contains "API Proposal"; the task belongs to project 1212149061863360 (API Proposals); or the description proposes changes to a -api module. Also invoke for any request to review, evaluate, or give feedback on a proposal pasted inline or provided as a file. Covers phrases like "review my API proposal", "is this API design good?", "check my public interface", "I'm about to submit an API proposal". When the user shares Kotlin code, only invoke if the code is explicitly from or intended for a -api module — do not invoke for impl-only changes or general Kotlin questions. IMPORTANT: Always apply these instructions directly — never delegate or summarise.

Uses Chrome DevTools via MCP for efficient debugging, troubleshooting and browser automation. Use when debugging web pages, automating browser interactions, analyzing performance, or inspecting network requests. This skill does not apply to `--slim` mode (MCP configuration).

Static-first Next.js 16 architecture patterns: cached shells with dynamic slots, provider islands, 'use cache' boundaries, and link preloading strategy. Use when building or refactoring Next.js routes to maximize static rendering, implementing 'use cache' with dynamic personalization, splitting entry vs static renderers, scoping client providers, or tuning prefetch behavior. Triggers on 'static shell', 'use cache pattern', 'dynamic slots', 'provider island', 'prefetch strategy', 'static first', 'cache boundary', 'route goes dynamic unexpectedly', or any Next.js architecture work involving mixed static/dynamic rendering.

Set up self-hosted Inngest on macOS as a durable background task manager for AI agents. Interactive Q&A to match intent — from Docker one-liner to full k8s deployment with persistent state. Use when: 'set up inngest', 'background tasks', 'durable workflows', 'self-host inngest', 'event-driven functions', 'cron jobs', or any request for a local workflow engine.

Extract abstract mathematical models from functional code (Haskell, OCaml, F#) for formal reasoning in Isabelle/HOL. Use when users need to: (1) Convert functional programs to Isabelle definitions, (2) Extract high-level algorithm essence from implementation code, (3) Generate formal specifications and properties from code, (4) Create verification-ready models that capture mathematical properties while abstracting away implementation details. Focuses on structural recursion, algebraic data types, higher-order functions, and invariant extraction.

Configure CI/CD pipelines for Fireflies.ai integrations with GraphQL testing. Use when setting up automated testing, configuring GitHub Actions, or validating Fireflies.ai queries in your build process. Trigger with phrases like "fireflies CI", "fireflies GitHub Actions", "fireflies automated tests", "CI fireflies", "test fireflies pipeline".

Implement real-time streaming transcription with Deepgram WebSocket. Use when building live transcription, voice interfaces, real-time captioning, or voice AI applications. Trigger: "deepgram streaming", "real-time transcription", "live transcription", "websocket transcription", "voice streaming", "deepgram live".

Optimize blockchain gas costs by analyzing prices, patterns, and timing. Use when checking gas prices, estimating costs, or finding optimal windows. Trigger with phrases like "gas prices", "optimize gas", "transaction cost", "when to transact".

Implements real-time WebSocket communication with connection management, room-based messaging, and horizontal scaling. Use when building chat systems, live notifications, collaborative tools, or real-time dashboards.