Simulate Nature-style or general pre-submission peer review from the referee perspective, not an author rebuttal. Use for reviewer reports, mock peer review, manuscript critique, novelty/significance/technical-soundness assessment, 审稿人视角评估, 模拟审稿, 预审, 投稿前自审, 审稿意见模拟, or 帮我审一下论文. Produce evidence-grounded Major Concerns, Minor Comments, and blocking flags. For multiple reviewers, keep every reviewer mutually blind in a separate context, freeze all reports before comparison, and create any synthesis only afterward as a separate editor/author-facing artifact.