solublempnn
Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering.
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Use this skill for solubility-aware protein design.
Workflow:
- Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
- Verify model availability and execution path before running.
- Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
- Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
- Attach assay or expression-screen recommendations when a decision depends on solubility.
Do not equate a solubility score with confirmed expression.
- Repository
- companion-inc/feynman
- Commit
95c51d9
- Last updated
- First committed
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