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encode-ccres-database

Query the ENCODE Registry of cis-Regulatory Elements (cCREs) via the SCREEN GraphQL API, or make custom queries to the ENCODE Portal REST API for experiments and files (ChIP-seq peaks, etc.). Use when you want to query regulatory annotations or raw experimental data across human cell types.

Quality

89%

Does it follow best practices?

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SKILL.md
Quality
Evals
Security

Quality

Content

86%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A well-structured, highly actionable command catalog with appropriate progressive disclosure to real reference files. Could tighten the duplicated parsing warning and add an explicit query-failure validation step.

Suggestions

De-duplicate the cat/jq parsing guidance — state it once and reference it, instead of repeating the full warning in both 'Core Rules' and 'Parsing Output (CRITICAL)'.

Add an explicit validation checkpoint for query results (e.g., check the output JSON for empty results or error fields before parsing with jq, and retry or report on failure).

Slightly tighten the 'Type A' biosample explanation to assume domain familiarity, since the four core markers are already enumerated.

DimensionReasoningScore

Conciseness

Mostly efficient and action-oriented, but the cat/jq parsing warning is repeated in both 'Core Rules' and the 'Parsing Output (CRITICAL)' section, and the 'Type A' biosample explanation could be trimmed slightly.

4 / 5

Actionability

Provides copy-paste-ready, fully executable `uv run scripts/...` commands with real flags and concrete accessions across search, details, biosamples, gwas, entex, and more, covering the common cases comprehensively.

5 / 5

Workflow Clarity

Clear, consistent sequence (run wrapper → save to /tmp → parse with jq) and sequenced prerequisites, with built-in resilience noted (rate limiting, mm10 fallback), but no explicit validation/error-recovery checkpoint for failed or empty queries.

4 / 5

Progressive Disclosure

Keeps the body as an overview with bulk reference material (JSON output structure, GraphQL schema) split into well-signaled, one-level-deep files in references/ that genuinely exist.

5 / 5

Total

18

/

20

Passed

Description

87%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, specific description that clearly states capabilities and an explicit use-when clause tied to a distinct genomics niche. Minor room to enumerate data types more fully and drop the vague 'etc.'.

DimensionReasoningScore

Specificity

Names concrete actions tied to specific APIs — 'Query the ENCODE Registry of cis-Regulatory Elements (cCREs) via the SCREEN GraphQL API' and 'make custom queries to the ENCODE Portal REST API for experiments and files (ChIP-seq peaks, etc.)' — but the trailing 'etc.' and broad 'files' leave minor coverage gaps versus a fully enumerated list.

4 / 5

Completeness

Explicitly answers both what (query cCREs via SCREEN GraphQL, custom REST queries for experiments/files) and when ('Use when you want to query regulatory annotations or raw experimental data across human cell types') with concrete trigger phrasing.

5 / 5

Trigger Term Quality

Includes natural domain terms a genomics user would say — 'regulatory annotations', 'raw experimental data', 'ChIP-seq peaks', 'human cell types', 'ENCODE', 'cCREs' — with good coverage, though a few synonyms (e.g. 'enhancers', 'promoters') are absent.

4 / 5

Distinctiveness Conflict Risk

Occupies a clear niche (ENCODE cCREs, SCREEN GraphQL, ENCODE Portal REST) with distinct, domain-specific triggers and minimal overlap risk with other skills.

5 / 5

Total

18

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository

google-deepmind/science-skills

Path

skills/encode_ccres_database/SKILL.md

Reviewed

Table of Contents

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