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ucsc-conservation-and-tfbs

Fetch Evolutionary Conservation scores (phyloP, phastCons) and Transcription Factor Binding Sites (TFBS) from the UCSC Genome Browser. Use when analyzing whether genomic variants or regions are evolutionarily conserved, functionally important, or bounded by TF regulators across major projects (ENCODE, JASPAR, ReMap).

Quality

87%

Does it follow best practices?

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SKILL.md
Quality
Evals
Security

Quality

Content

68%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

The body is highly actionable, with executable commands covering each capability and a well-sectioned structure that points to real helper scripts. It is held back by tutorial-style conceptual prose and by batch/large-output workflows that lack explicit validation checkpoints.

Suggestions

Trim the conceptual explanations of PHAST/phastCons/phyloP and 'HMM smoothing' / pathogenicity rationale to one line each, keeping only what drives the choice of metric.

Add an explicit verification step after large-output queries (e.g., 'jq .summary /tmp/cons_output.json' or check the record count / non-empty result) to give the batch workflow a validate→retry feedback loop and lift workflow_clarity above 3.

Either reference references/citation.bib from the body (e.g., in a citation requirement for downstream publication) or move the per-genome collection tables into a reference file to complete the progressive-disclosure split.

DimensionReasoningScore

Conciseness

Mostly efficient with copy-paste commands, but retains tutorial prose that assumes less than Claude knows — e.g. 'retrieves scores from the PHAST package — specifically phastCons (identifying functional blocks) and phyloP (measuring individual site constraint) — calculated from multiple alignments' and 'phastCons is best for functional windows due to HMM smoothing', which could be trimmed without losing actionability.

3 / 5

Actionability

Fully executable, copy-paste-ready `uv run scripts/...` commands with all flags (--coordinates, --collection, --conserved-elements, --analyze, --tracks, --tf-filter, --output) cover the common cases across variants, regions, lineage depth, acceleration, TFBS, and track listing.

5 / 5

Workflow Clarity

The Prerequisites are sequenced and core rules flag rate-limiting and large-output handling, but the batch/large-output query workflow has no explicit validate→fix→retry feedback loop; per the rubric, a batch operation missing validation is capped at 3.

3 / 5

Progressive Disclosure

Well-organized into headed sections with one-level-deep references to real bundle files (scripts/get_conservation.py, get_tfbs.py, list_tracks.py all present); the unused references/citation.bib and the inlined per-genome collection tables are minor organization gaps rather than a clean split, keeping it just below a 5.

4 / 5

Total

15

/

20

Passed

Description

100%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, third-person description that concretely states the skill's two actions and pairs them with an explicit, well-keyworded 'Use when' trigger clause. It is comprehensive, distinct, and free of fluff.

DimensionReasoningScore

Specificity

Lists multiple concrete actions — 'Fetch Evolutionary Conservation scores (phyloP, phastCons) and Transcription Factor Binding Sites (TFBS) from the UCSC Genome Browser' — with comprehensive coverage of the skill's two capabilities.

5 / 5

Completeness

Explicitly answers both what ('Fetch... scores... and TFBS from the UCSC Genome Browser') and when ('Use when analyzing whether genomic variants or regions are evolutionarily conserved...'), with concrete trigger phrases.

5 / 5

Trigger Term Quality

Covers natural user phrasing — 'genomic variants or regions', 'evolutionarily conserved', 'functionally important', 'TF regulators' — plus project synonyms (ENCODE, JASPAR, ReMap) a genomics user would actually say.

5 / 5

Distinctiveness Conflict Risk

A clear niche (UCSC conservation + TFBS lookup) anchored by distinctive triggers (phyloP, phastCons, ENCODE, JASPAR, ReMap) gives minimal overlap with other skills.

5 / 5

Total

20

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository

google-deepmind/science-skills

Path

skills/ucsc_conservation_and_tfbs/SKILL.md

Reviewed

Table of Contents

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