tooluniverse-acmg-variant-classification
Systematic ACMG/AMP germline variant classification with all 28 criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) for clinical significance. Produces 5-tier verdict (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with cited evidence per criterion. Use for variant interpretation, VUS resolution, and pathogenicity assessment. Combines ClinVar, gnomAD, computational predictors, and gene-mechanism context.
73
92%
Does it follow best practices?
Run evals on this skill
Adds up to 20 points to the overall score
Low
Low-risk findings worth noting
The canonical home for this skill is tooluniverse-acmg-variant-classification in mims-harvard/ToolUniverse
W011: Third-party content exposure detected (indirect prompt injection risk).
What this means
The skill exposes the agent to untrusted, user-generated content from public third-party sources, creating a risk of indirect prompt injection. This includes browsing arbitrary URLs, reading social media posts or forum comments, and analyzing content from unknown websites.
Why it was flagged
The required workflow calls various bioinformatics APIs (ClinVar, gnomAD, PubMed, MyVariant, etc.) to query variant databases, where database query responses and literature search results contain outsider-authored free text.
- Audited
- Security analysis
Is this your skill?
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