Therapeutic antibody engineering and optimization, lead-to-clinical-candidate. Covers sequence humanization (germline alignment, framework retention), affinity maturation, developability (aggregation, stability, PTMs), structure modeling (AlphaFold/PDB CDR analysis), immunogenicity prediction, and manufacturing feasibility. Use for biologic-drug optimization, mAb design review, biosimilar engineering, and clinical-precedent comparison.
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Low
Low-risk findings worth noting
Low
Low-risk findings.
1 low severity finding. Worth noting, but not necessarily harmful.
The skill exposes the agent to untrusted, user-generated content from public third-party sources, creating a risk of indirect prompt injection. This includes browsing arbitrary URLs, reading social media posts or forum comments, and analyzing content from unknown websites.
The required runtime workflow ingests user-supplied sequences/fields via the `analyze(... vh_sequence, vl_sequence, target_antigen)` path, and those values are then used as free-text query inputs to external LLM tools like `iedb_search_epitopes(...)` and structure/precedent search calls (e.g., `TheraSAbDab_search_by_target`, `SAbDab_search_structures`).
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