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tooluniverse-cancer-variant-interpretation

Clinical interpretation of somatic cancer mutations for precision oncology. Transforms a gene + variant + cancer-type input into an actionable report: clinical evidence tier (CIViC, OncoKB), therapeutic options (FDA-approved + investigational), resistance mechanisms, prognosis, and matching clinical trials. Use for tumor-board variant calls, somatic-mutation actionability assessment, and treatment selection. Always cancer-type-specific.

Quality

81%

Does it follow best practices?

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SecuritybySnyk

Passed

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SKILL.md
Quality
Evals
Security

Quality

Content

60%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

The body delivers strong operational intelligence (verified parameters, response shapes, fallbacks, and clinical reasoning tiers) but is undercut by a dangling reference to a nonexistent ANALYSIS_DETAILS.md and inline bulk that belongs in reference files. Conceptual biology explanations Claude already knows pad the token cost.

Suggestions

Create the referenced ANALYSIS_DETAILS.md with the per-phase code snippets and API call patterns, or remove the reference at line 111.

Move the long tool-reference tables (Gene Resolution, Drug Information, Mutation Prevalence, etc.) into a separate reference file (e.g., references/TOOL_REFERENCE.md) and keep only the most-used tools in SKILL.md.

Trim explanations of concepts Claude already knows (oncogene vs tumor suppressor roles, driver/passenger basics) down to the tool-specific decision guidance.

DimensionReasoningScore

Conciseness

The tool-parameter tables and verified response fields are dense, high-value content, but the body re-explains biology Claude already knows (e.g., 'Genes like EGFR, BRAF, KRAS, TP53, PIK3CA are well-established cancer drivers', 'Not every mutation in a tumor is driving the cancer') and several justification paragraphs could be trimmed.

3 / 5

Actionability

Concrete tool names, exact parameter corrections ('ensemblId (camelCase)', 'ALL 4 required'), response key fields, and a verified worked example make most guidance executable. However, per-phase 'detailed code snippets and API call patterns' are deferred to ANALYSIS_DETAILS.md, which does not exist in the bundle.

4 / 5

Workflow Clarity

A clear 8-phase sequence with a Phase 0 parameter-verification checkpoint, an explicit fallback strategy, and a documented retry-once behavior for IntOGen timeouts. Checkpoints remain at overview level since per-phase detail is deferred to the missing reference file.

4 / 5

Progressive Disclosure

The sole reference, 'For detailed code snippets and API call patterns for each phase, see ANALYSIS_DETAILS.md', points to a file that does not exist, and large tool-reference tables that belong in a separate file are inlined in SKILL.md.

2 / 5

Total

13

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

The description is specific, complete, and clearly niched: it states concrete report outputs and an explicit 'Use for' clause with natural clinical triggers. Its only weakness is modest synonym coverage of the phrasings a user might naturally type.

DimensionReasoningScore

Specificity

The description enumerates five concrete output capabilities ('clinical evidence tier (CIViC, OncoKB), therapeutic options (FDA-approved + investigational), resistance mechanisms, prognosis, and matching clinical trials') with comprehensive coverage and no gaps.

5 / 5

Completeness

Explicitly answers both what ('Transforms a gene + variant + cancer-type input into an actionable report...') and when ('Use for tumor-board variant calls, somatic-mutation actionability assessment, and treatment selection') with concrete trigger phrases.

5 / 5

Trigger Term Quality

Natural phrases like 'tumor-board variant calls', 'somatic-mutation actionability assessment', and 'treatment selection' are present, but common user phrasings such as 'is this variant targetable', 'targeted therapy', or specific gene/variant mentions are missing.

4 / 5

Distinctiveness Conflict Risk

'somatic cancer mutations' plus 'Always cancer-type-specific' carves a clear niche distinct from germline interpretation or general genetics skills, with minimal overlap risk.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository

mims-harvard/ToolUniverse

Path

plugin/skills/tooluniverse-cancer-variant-interpretation/SKILL.md

Revision

99b81eb

Reviewed

Table of Contents

DiscoveryImplementationValidation

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