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tooluniverse-clinical-data-integration

End-to-end drug safety review integrating FDA labels, FAERS adverse event reports, PRR/ROR disproportionality, pharmacogenomic biomarkers, clinical trial data, and published literature. Use for regulatory drug safety reviews, comprehensive pharmacovigilance reports, label-vs-real-world AE comparison, and clinical decision support for drug safety.

Quality

85%

Does it follow best practices?

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Adds up to 20 points to the overall score

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SecuritybySnyk

Low

Low-risk findings worth noting

The canonical home for this skill is tooluniverse-clinical-data-integration in mims-harvard/ToolUniverse

SKILL.md
Quality
Evals
Security

Quality

Content

71%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A well-structured, highly actionable phase-by-phase pipeline with exact tool contracts, decision thresholds, and edge-case fallbacks. Its main weakness is progressive disclosure: it is a single ~290-line monolith with no bundle files, inlining per-tool API detail and interpretation tables that should live in referenced files.

Suggestions

Move per-tool input/output contracts and the FAERS interpretation tables into references/ files (e.g., references/tools.md, references/faers-interpretation.md), keeping SKILL.md as a lean overview with one-level-deep pointers.

Add a short executable example in 'COMPUTE, DON'T DESCRIBE' (e.g., a sample FAERS disproportionality call followed by a pandas/scipy analysis) so the compute mandate is copy-paste ready.

Either integrate the data-harmonization guidance (ICD-10/SNOMED, informative missing data) into a specific phase or cut it, and add explicit validation checkpoints such as confirming the resolved SPL/drug identity before running Phase 1 queries.

DimensionReasoningScore

Conciseness

The body is dense and operational — tool I/O contracts, parameter gotchas, and thresholds — with no padding on basics Claude already knows. A few sections could be trimmed, e.g., the unanchored data-harmonization paragraph (ICD-10 vs SNOMED, missing lab values) that is not tied to any phase.

4 / 5

Actionability

Every tool lists exact inputs/outputs ('medicinalproduct' not 'drug_name', 'setid' NOT 'set_id', 'limit=1000') plus explicit signal criteria (PRR >= 2.0, lower CI > 1.0, N >= 3). Minor gap: 'COMPUTE, DON'T DESCRIBE' mandates Python analysis but provides no example call or code snippet.

4 / 5

Workflow Clarity

Clear Phase 0-6 sequence with per-phase objectives, tools, workflows, decision criteria, error-handling notes ('NOT_FOUND response for boxed warnings is normal', MedDRA term mismatch), edge cases, and evidence grading. Falls short of a 5 because it lacks explicit feedback loops, e.g., re-validating resolved drug identity before proceeding.

4 / 5

Progressive Disclosure

No bundle files exist (references/, scripts/, assets/ are absent) and the ~290-line body inlines reference-grade material — per-tool API detail, FAERS interpretation tables, signal-credibility criteria — that belongs in separate reference files with pointers from the overview. Well-sectioned, but the split is overdue.

3 / 5

Total

15

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong description: it states concrete capabilities with named data sources and methods, and includes an explicit 'Use for...' clause with four concrete trigger scenarios. Only minor improvement possible by adding a few more natural user synonyms (e.g., 'side effects', 'post-market surveillance').

DimensionReasoningScore

Specificity

The description lists multiple concrete integrated capabilities and data sources ('FDA labels, FAERS adverse event reports, PRR/ROR disproportionality, pharmacogenomic biomarkers, clinical trial data, and published literature') in third-person voice, with comprehensive coverage of the review pipeline and no gaps.

5 / 5

Completeness

Explicitly answers both what ('End-to-end drug safety review integrating FDA labels, FAERS adverse event reports...') and when ('Use for regulatory drug safety reviews, comprehensive pharmacovigilance reports, label-vs-real-world AE comparison, and clinical decision support for drug safety') with concrete trigger phrases.

5 / 5

Trigger Term Quality

Good natural keyword coverage ('drug safety review', 'adverse event', 'pharmacovigilance', 'regulatory', 'clinical decision support'), but common user synonyms like 'side effects' or 'post-market surveillance' are missing and 'PRR/ROR disproportionality' is technical jargon.

4 / 5

Distinctiveness Conflict Risk

Occupies a clear regulatory-grade drug safety integration niche with distinct, highly specific triggers; near-zero overlap risk with generic skills, and the body even differentiates it from sibling pharmacovigilance skills.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository

mims-harvard/ToolUniverse

Path

plugins/tooluniverse/skills/tooluniverse-clinical-data-integration/SKILL.md

Reviewed

Table of Contents

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