CtrlK
BlogDocsLog inGet started
Tessl Logo

tooluniverse-comparative-genomics

Cross-species gene comparison and ortholog analysis. Integrates Ensembl Compara orthologs, NCBI Gene, UniProt, OLS, Monarch, and OpenTargets to identify orthologs, paralogs, sequence conservation, functional conservation across species, and lineage-specific gene gains/losses. Use for phylogenetic gene tracing, model-organism mapping, and evolutionary-genomics queries.

62

Quality

73%

Does it follow best practices?

Run evals on this skill

Adds up to 20 points to the overall score

View guide

SecuritybySnyk

Passed

No findings from the security scan

Fix and improve this skill with Tessl

tessl review fix ./plugins/tooluniverse/skills/tooluniverse-comparative-genomics/SKILL.md

The canonical home for this skill is tooluniverse-comparative-genomics in mims-harvard/ToolUniverse

SKILL.md
Quality
Evals
Security

Quality

Content

67%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A detailed, actionable comparative-genomics skill with a clear six-phase workflow, concrete tool signatures, real fallback strategies, and a genuine bundled script. Weakest on conciseness, where a conceptual reasoning framework restates evolutionary-genomics knowledge Claude already has.

Suggestions

Trim the "Conservation Reasoning Framework" to tool-specific guidance and thresholds, dropping the general explanations of ortholog relationship types and dN/dS interpretation that Claude already knows — keep only the data path (`ensembl_get_homology` → CDS → `Sequence_dn_ds`) and the PhastCons/GERP/dN-dS cutoffs.

Make per-phase validation checkpoints explicit (e.g., "After Phase 2: confirm at least one 1:1 ortholog exists before proceeding to sequence retrieval") rather than leaving them implicit in the Fallback Strategies section.

Promote the full tool-parameter reference into a separate `references/tools.md` so SKILL.md stays a lean overview, with the key call signatures linked one level deep.

DimensionReasoningScore

Conciseness

The body is mostly efficient and tool-specific (exact parameters, return shapes, thresholds, fallbacks), but the "Conservation Reasoning Framework" section spends prose explaining concepts Claude already knows (1:1 vs 1:many orthologs, dN/dS interpretation, purifying selection) that could be tightened without losing the tool-specific value.

3 / 5

Actionability

Provides concrete executable guidance throughout — `EnsemblCompara_get_orthologues(gene, species, target_species)`, `Sequence_dn_ds(seq1="ATG...", seq2="ATG...")`, `UniProt_search("gene:TP53 AND organism_id:9606 AND reviewed:true")`, and the bundled `scripts/dnds.py` with usage — with only minor gaps where calls are described at parameter level rather than as full runnable blocks.

4 / 5

Workflow Clarity

A clearly sequenced six-phase workflow (with an ASCII pipeline diagram), per-phase reasoning, a Fallback Strategies section for error recovery, and Synthesis Questions acting as a review checklist; it is a read-only analysis workflow so the destructive/batch validation cap does not apply, but explicit per-phase validation checkpoints are mostly implicit rather than called out.

4 / 5

Progressive Disclosure

Well-organized with clear section headers and one-level-deep, clearly signaled references (the bundled `scripts/dnds.py` and a sibling `tooluniverse-microbial-genome-characterization` skill) with no nested reference chains; the bulk of tool/parameter detail is inline, which is reasonable at this size but leaves minor organization gaps.

4 / 5

Total

15

/

20

Passed

Description

78%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, specific description that clearly states both capability and use contexts with a distinct niche and named integrations. The main improvement would be making the trigger phrasing map more directly to user utterances and tightening a couple of concept-as-action wordings.

DimensionReasoningScore

Specificity

Names the domain and several concrete actions — "identify orthologs, paralogs, sequence conservation, functional conservation across species, and lineage-specific gene gains/losses" — plus six integrated data sources, giving comprehensive but slightly abstract action verbs ("sequence conservation" is a concept rather than a crisp action).

4 / 5

Completeness

Explicitly answers both "what" (cross-species comparison integrating named tools to identify orthologs/paralogs/conservation) and "when" ("Use for phylogenetic gene tracing, model-organism mapping, and evolutionary-genomics queries"), with the "when" listing concrete use contexts but not phrased as direct user-utterance triggers.

4 / 5

Trigger Term Quality

Includes natural specialist terms users would say — "ortholog", "cross-species gene comparison", "phylogenetic gene tracing", "model-organism mapping" — with good coverage, though a few common synonyms (e.g. "homolog", "gene family", "evolution") are only partially present.

4 / 5

Distinctiveness Conflict Risk

Occupies a clear niche (comparative genomics / ortholog analysis) anchored by named tools (Ensembl Compara, NCBI Gene, UniProt, OLS, Monarch, OpenTargets), making it highly distinguishable with minimal conflict risk against other skills.

5 / 5

Total

17

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

Is this your skill?

If you maintain this skill, you can claim it as your own. Once claimed, you can manage eval scenarios, bundle related skills, attach documentation or rules, and ensure cross-agent compatibility.