Content
50%Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.
A dense, domain-rich body with concrete thresholds, tool parameters, and a well-sequenced eight-phase workflow, plus correctly bundled reference gene sets. Its main weaknesses are redundancy with the description, a Quick Start whose helper functions are undefined, dead 'See Also' links, and the absence of explicit inter-phase validation feedback loops.
Suggestions
Tighten conciseness: drop the restated intro line and the 'CRISPR screens enable genome-wide functional genomics…' concept sentence, and collapse the Overview phase list into the Core Workflow to avoid duplicating the eight phases.
Make the Quick Start executable: either define or import the helper functions it calls (load_sgrna_counts, mageck_gene_scoring, enrich_essential_genes, prioritize_drug_targets, generate_crispr_report), or label them explicitly as illustrative pseudocode and point to where the real implementations live.
Resolve progressive disclosure: create the referenced 'See Also' files or remove the dead links, and consider moving the detailed per-phase code and tool-param tables into ANALYSIS_DETAILS.md so SKILL.md stays an overview.
| Dimension | Reasoning | Score |
|---|---|---|
Conciseness | Mostly efficient domain content, but 'Comprehensive skill for analyzing CRISPR-Cas9 genetic screens…' restates the description, 'CRISPR screens enable genome-wide functional genomics…' explains a concept Claude knows, and the Overview re-lists the eight phases that are re-detailed in Core Workflow. | 2 / 3 |
Actionability | Concrete thresholds and tool params (LFC < -1.0, BF > 5, 50/30/20 weights, real reference_gene_sets import) are actionable, but the Quick Start calls undefined helper functions (load_sgrna_counts, mageck_gene_scoring, …) that are not importable, so the headline example is not copy-paste ready. | 2 / 3 |
Workflow Clarity | A clear eight-phase sequence exists with checkpoints (RULE ZERO pre-check, Phase 2 QC, recovery_rate, evidence grading), but there are no explicit inter-phase 'validate → fix → retry' feedback loops tying the phases together. | 2 / 3 |
Progressive Disclosure | Real one-level-deep script references exist and are correctly linked (scripts/reference_gene_sets.py, CEGv2/NEGv1 files verified present), but the five 'See Also' files (ANALYSIS_DETAILS.md, USE_CASES.md, EXAMPLES.md, QUICK_START.md, FALLBACK_PATCH.md) do not exist in the bundle, and the core workflow remains largely inline. | 2 / 3 |
Total | 8 / 12 Passed |