tooluniverse-drug-drug-interaction

Assess drug-drug interactions — CYP metabolic interactions (substrate/inhibitor/inducer), transporter (P-gp, BCRP, OATP) effects, pharmacodynamic synergy/antagonism, clinical significance scoring, and management recommendations. Use for polypharmacy review, prescribing decision support, and safety analysis when adding or switching drugs.

Quality

83%

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Securityby

Low

Low-risk findings worth noting

Quality

Content

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Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

The skill body is highly actionable with a clear phased workflow and a real offline reference script, but it is verbose in explaining general pharmacology and inlines material that would be better split into reference files.

Suggestions

Trim general pharmacology exposition (perpetrator-victim basics, induction/inhibition timing, glucuronidation mechanics) to the non-obvious essentials to improve conciseness.

Move the full covered-interactions table and UGT tutorial into a references/ file, keeping only a short pointer and the highest-value example in SKILL.md.

Add an explicit validate-fix-retry checkpoint (e.g., re-run failed tool calls or re-grade evidence before finalizing) to the workflow to strengthen error recovery.

Dimension	Reasoning	Score
Conciseness	The body is mostly efficient but spends substantial prose explaining general pharmacology Claude already knows (perpetrator-victim basics, induction/inhibition timing, glucuronidation mechanics), which could be tightened despite the genuinely non-obvious UGT1A4 core.	3 / 5
Actionability	Copy-paste-ready pharmacology_ref.py invocations with real flags, a concrete covered-interactions table, an explicit numeric risk-scoring formula, named external tools, and a precise report-file naming scheme make the guidance fully executable across common cases.	5 / 5
Workflow Clarity	A clear Phase 1-6 sequence, a MANDATORY report-first workflow, and a Success Criteria checklist provide most checkpoints, but there is no explicit validate-fix-retry error-recovery loop on the analysis itself.	4 / 5
Progressive Disclosure	The single bundle file (scripts/pharmacology_ref.py) is real and clearly referenced one level deep with well-organized sections, but the SKILL.md inlines reference-style material (full interaction table, UGT tutorial, severity prose) that could be split into separate files.	4 / 5
	Total	16 / 20 Passed

Description

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Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

The description is specific, complete, and clearly scoped to drug-drug interaction analysis with explicit 'what' and 'when' guidance. It is near-exemplary, with only minor room for more trigger-term synonyms.

Dimension	Reasoning	Score
Specificity	Lists multiple concrete actions — CYP substrate/inhibitor/inducer assessment, transporter (P-gp/BCRP/OATP) effects, pharmacodynamic synergy/antagonism, clinical significance scoring, and management recommendations — giving comprehensive coverage rather than just 1-2 actions.	5 / 5
Completeness	Explicitly answers both 'what' (the enumerated assessment capabilities) and 'when' ('Use for polypharmacy review, prescribing decision support, and safety analysis when adding or switching drugs') with concrete trigger phrases.	5 / 5
Trigger Term Quality	Natural user phrases like 'polypharmacy review', 'prescribing decision support', 'safety analysis', and 'adding or switching drugs' are present, but a few common synonyms (e.g., 'medication interactions') are missing relative to the comprehensive-synonym anchor.	4 / 5
Distinctiveness Conflict Risk	A clear specialized DDI-analysis niche with distinct triggers; unlikely to fire for unrelated skills, so conflict risk is minimal.	5 / 5
	Total	19 / 20 Passed

Validation

100%

Warnings & errors only

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository: mims-harvard/ToolUniverse
Path: plugin/skills/tooluniverse-drug-drug-interaction/SKILL.md
Commit: 1b02920

Reviewed: 1 day ago

Table of Contents

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