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tooluniverse-epigenomics

Genomics and epigenomics analysis: DNA methylation (CpG, 5mC, 5hmC, bisulfite, RRBS), m6A RNA modification (MeRIP-seq), ChIP-seq peaks, ATAC-seq accessibility, histone modifications, chromatin state, multi-omics integration. Combines pandas/scipy/pysam computation with ToolUniverse annotation tools. Use for genome-wide epigenomic statistics, methylation analysis, and chromatin-genome integration.

68

Quality

81%

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SecuritybySnyk

Passed

No findings from the security scan

SKILL.md
Quality
Evals
Security

Quality

Content

67%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

Highly actionable content with strong pitfall guidance and a clear workflow, undermined by missing reference files that break progressive disclosure and some repetition across sections.

Suggestions

Create the referenced files (ANALYSIS_PROCEDURES.md, CODE_REFERENCE.md, TOOLS_REFERENCE.md, QUICK_START.md) under references/, or remove the dangling references from the body.

Consolidate the three repeated rows-vs-unique-sites explanations into a single canonical section to reduce token cost.

Trim generic sections like 'Key Principles' and 'LOOK UP, DON'T GUESS' that restate what Claude already knows.

DimensionReasoningScore

Conciseness

Mostly efficient and rich in non-obvious pitfalls, but the rows-vs-sites distinction is restated three times and 'Key Principles'/'LOOK UP, DON'T GUESS' add some generic padding that could be trimmed.

3 / 5

Actionability

Copy-paste-ready script invocation with concrete args, question-to-field mapping tables, and specific tool parameter guidance (e.g. GTEx uses gene_symbol NOT Ensembl ID, ensembl_get_regulatory_features needs NO chr prefix).

5 / 5

Workflow Clarity

RULE ZERO checkpoint and an explicit sanity-check feedback loop ('Re-run with the other axis and compare') anchor a clear phased workflow; minor validation gaps in the later batch phases keep it just below 5.

4 / 5

Progressive Disclosure

The bundled script reference is real, but the body references four markdown files (ANALYSIS_PROCEDURES.md, CODE_REFERENCE.md, TOOLS_REFERENCE.md, QUICK_START.md) that do not exist in the references/ bundle, leaving navigation broken.

2 / 5

Total

14

/

20

Passed

Description

95%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, comprehensive description that explicitly covers what it does and when to use it with rich natural keywords. Only minor weakness is slightly generic action verbs versus the most concrete anchor examples.

DimensionReasoningScore

Specificity

Names many concrete modalities (CpG, 5mC, 5hmC, bisulfite, RRBS, MeRIP-seq, ChIP-seq, ATAC-seq) and the computation stack (pandas/scipy/pysam), though action verbs like 'analysis' and 'integration' are slightly less concrete than extract/fill/merge anchors.

4 / 5

Completeness

Explicitly answers both 'what' (modalities, computation stack, ToolUniverse annotation) and 'when' via a clear 'Use for ...' clause with concrete trigger phrases.

5 / 5

Trigger Term Quality

Comprehensive natural keyword coverage with synonyms and assay names (CpG, 5mC, 5hmC, bisulfite, RRBS, MeRIP-seq, ChIP-seq, ATAC-seq, histone, chromatin) that users would naturally say.

5 / 5

Distinctiveness Conflict Risk

Occupies a clear epigenomics niche with distinct trigger terms; minimal overlap risk with RNA-seq/variant/protein skills.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

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