Content
62%Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.
The body provides a strong, well-sequenced workflow with explicit sanity-check feedback loops and a concrete primary script, but it is held back by repeated rows-vs-sites explanation, descriptive secondary phases, and references to four bundle files that are missing.
Suggestions
Consolidate the rows-vs-sites guidance, which is currently explained in three places with two overlapping question-phrasing tables, into a single section to cut redundancy.
Provide the missing referenced files (CODE_REFERENCE.md, TOOLS_REFERENCE.md, ANALYSIS_PROCEDURES.md, QUICK_START.md) or remove the references and inline the necessary detail, since the bundle currently contains only scripts/methylation_density.py.
Add executable code snippets for the Phase 1–7 analyses (e.g., differential methylation, chromosome density) rather than high-level bullets, given that the detailed implementations are delegated to a nonexistent CODE_REFERENCE.md.
| Dimension | Reasoning | Score |
|---|---|---|
Conciseness | Mostly efficient domain-specific guidance, but the rows-vs-sites pitfall is explained three times (TOP-OF-MIND RULE, PRIMARY SCRIPT section, and the "Distinguish rows vs unique sites" section) with two overlapping question-phrasing tables that could be merged, so it fits the score-2 "could be tightened" anchor rather than the lean score-3 anchor. | 2 / 3 |
Actionability | The primary script invocation is fully executable and copy-paste ready ("python skills/.../methylation_density.py --cpg ... --chr-lengths ... --filter-meth-extremes 90 10") with a concrete output-field table, but Phases 1–7 are high-level bullets (e.g., "Differential methylation: T-test/Wilcoxon between groups + FDR") and delegate implementations to CODE_REFERENCE.md, which is not present in the bundle, leaving key details missing as in the score-2 anchor. | 2 / 3 |
Workflow Clarity | A clearly sequenced Phase 0–7 workflow with RULE ZERO precedence and explicit feedback loops ("Sanity check: if your filtered count is two orders of magnitude smaller than the GT range ... Re-run with the other axis and compare") matches the score-3 anchor of clear sequence with explicit validation and error-recovery checkpoints; operations are analytical/read-only rather than destructive, so the destructive-cap does not apply. | 3 / 3 |
Progressive Disclosure | References are one-level-deep and clearly signaled (inline "See CODE_REFERENCE.md" plus a Reference Files list), but four referenced files (CODE_REFERENCE.md, TOOLS_REFERENCE.md, ANALYSIS_PROCEDURES.md, QUICK_START.md) do not exist in the bundle — only scripts/methylation_density.py is present — so navigation leads nowhere and the structure is only partly realized, fitting the score-2 "could be better organized" anchor rather than the well-split score-3 anchor. | 2 / 3 |
Total | 9 / 12 Passed |