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tooluniverse-gene-liability

Evaluate the human safety liability of knocking down, knocking out, degrading, or pharmacologically inhibiting a gene. Use for gene safety scoring, on-target toxicity assessment, essentiality and genetic-constraint review, critical-organ expression analysis, or deciding whether a target needs partial, transient, or tissue-specific modulation.

69

Quality

83%

Does it follow best practices?

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SecuritybySnyk

Passed

No findings from the security scan

SKILL.md
Quality
Evals
Security

Quality

Content

75%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

The body is a dense, well-structured instruction skill with concrete tool invocations, exact scoring thresholds, and clear validation gating. It is efficient and actionable but lacks a worked end-to-end example and a true retry loop, and is monolithic rather than split across reference files.

Suggestions

Add one fully worked example (e.g. a sample gene with retrieved evidence, per-dimension points, the computed liability score, coverage, and confidence) to lift actionability to copy-paste-ready.

Introduce an explicit validate-fix-retry loop for the low-coverage case (e.g. 'if coverage < 60%, identify the highest-value missing dataset, re-query its fallback, then re-score') to strengthen workflow_clarity.

Consider moving the per-dimension point anchors (0/5/15/25 etc.) into a references/scoring-anchors.md file referenced one level deep, keeping SKILL.md as a tighter overview.

DimensionReasoningScore

Conciseness

Largely lean and instructional with no over-explanation of basic biology, but a few disambiguation sentences ("This is a safety score, not a target-efficacy or druggability score") could be trimmed, so it sits just below the top anchor.

4 / 5

Actionability

Concrete, parameterized tool calls (e.g. `MyGene_query_genes` with `species="human"`, `gnomad_get_gene_constraints(gene_symbol=...)`) and exact scoring anchors make guidance mostly executable; the minor gap is the absence of a full worked end-to-end example.

4 / 5

Workflow Clarity

Five clearly numbered steps with explicit gating checkpoints (stop on ambiguous locus, coverage >= 60% to publish a categorical score, fallback-or-unavailable handling); falls short of the top anchor because there is no true validate-fix-retry error-recovery loop.

4 / 5

Progressive Disclosure

Well-organized into clear sections (Required Input, Evidence Rules, Workflow, Required Output) with no nested file references, but the skill is a single ~175-line monolith with no bundle files; the detailed per-dimension scoring anchors could optionally live in a separate reference file.

4 / 5

Total

16

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

The description is specific, complete, and distinctive: it states concrete intervention modalities and a clear 'Use for...' trigger clause covering multiple natural use cases. It uses correct third-person voice and avoids vague fluff.

DimensionReasoningScore

Specificity

Lists multiple concrete intervention actions ("knocking down, knocking out, degrading, or pharmacologically inhibiting a gene") plus several distinct use cases, giving comprehensive coverage of the skill's capabilities.

5 / 5

Completeness

Explicitly answers both what ("Evaluate the human safety liability...") and when ("Use for gene safety scoring, on-target toxicity assessment...") with concrete trigger phrases, satisfying the top anchor.

5 / 5

Trigger Term Quality

Strong natural domain keywords ("gene safety scoring", "on-target toxicity assessment", "essentiality and genetic-constraint review", "critical-organ expression analysis") that a target-validation scientist would say, though a few common synonyms (e.g. "target validation", "druggability", "toxicology") are absent.

4 / 5

Distinctiveness Conflict Risk

Occupies a clear niche (human gene safety liability for target modulation) with distinct, specialized triggers and minimal overlap risk with other skills.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

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