CtrlK
BlogDocsLog inGet started
Tessl Logo

tooluniverse-gwas-snp-interpretation

Interpret a single GWAS SNP across multiple databases — GWAS Catalog hits, LD/haplotype context, eQTL evidence, regulatory annotation, ClinVar pathogenicity, gnomAD frequency. Use for 'what does this SNP do', SNP-to-mechanism tracing, and resolving lead-SNP-vs-causal-variant ambiguity. Always considers LD structure before claiming a SNP is mechanistically responsible.

64

Quality

75%

Does it follow best practices?

Run evals on this skill

Adds up to 20 points to the overall score

View guide

SecuritybySnyk

Passed

No findings from the security scan

Fix and improve this skill with Tessl

tessl review fix ./plugins/tooluniverse/skills/tooluniverse-gwas-snp-interpretation/SKILL.md

The canonical home for this skill is tooluniverse-gwas-snp-interpretation in mims-harvard/ToolUniverse

SKILL.md
Quality
Evals
Security

Quality

Content

57%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

The content is well-structured and actionable with concrete tool calls, but is verbose in places, lacks explicit validation checkpoints in its workflow, and references a missing QUICK_START.md file.

Suggestions

Add explicit validation checkpoints to the workflow (e.g., verify the rs_id resolves before proceeding, confirm each API returned non-empty results before aggregating).

Trim sections Claude already knows — the p-value significance table, L2G score bands, and database coverage statistics — to reduce token cost.

Either provide the referenced QUICK_START.md or remove the dangling 'See QUICK_START.md' pointer; consider moving the full JSON output schemas into a reference file.

DimensionReasoningScore

Conciseness

The body is ~220 lines with sections Claude largely already knows (p-value significance thresholds, L2G score bands, coverage statistics) and lengthy illustrative JSON output blocks that could be tightened.

3 / 5

Actionability

It names concrete tools with parameters and defaults (e.g. 'gwas_get_snp_by_id', 'OpenTargets_get_variant_credible_sets', 'LDlink_get_proxies(variant="rs...", population="EUR")') and an output schema, but the example section defers to a nonexistent QUICK_START.md, leaving a minor gap.

4 / 5

Workflow Clarity

A clear 5-step workflow with per-step tools is present, but there are no explicit validation checkpoints or verify-then-proceed feedback loops wired into the sequence.

3 / 5

Progressive Disclosure

Good section structure exists, but the one signaled reference ('See QUICK_START.md') points to a file that is not present in the bundle, and reference-like bulk (full JSON output schemas, interpretation guide) is inlined rather than split out.

3 / 5

Total

13

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, specific description that clearly states capabilities and usage triggers with a well-defined niche. It is slightly technical in its trigger phrasing, which keeps trigger-term quality just short of the top anchor.

DimensionReasoningScore

Specificity

The description enumerates multiple concrete data actions — 'GWAS Catalog hits, LD/haplotype context, eQTL evidence, regulatory annotation, ClinVar pathogenicity, gnomAD frequency' — giving comprehensive coverage of what the skill does.

5 / 5

Completeness

It explicitly answers both 'what' (interpret a SNP across the listed databases) and 'when' ('Use for ...' with concrete trigger phrases), matching the top anchor.

5 / 5

Trigger Term Quality

It includes the natural phrase 'what does this SNP do' plus technical triggers like 'SNP-to-mechanism tracing' and 'lead-SNP-vs-causal-variant ambiguity', but is somewhat jargon-heavy and misses lay synonyms a user might say.

4 / 5

Distinctiveness Conflict Risk

The GWAS SNP interpretation niche is highly specific with distinct triggers, creating minimal conflict risk with other skills.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

Is this your skill?

If you maintain this skill, you can claim it as your own. Once claimed, you can manage eval scenarios, bundle related skills, attach documentation or rules, and ensure cross-agent compatibility.