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tooluniverse-gwas-snp-interpretation

Interpret a single GWAS SNP across multiple databases — GWAS Catalog hits, LD/haplotype context, eQTL evidence, regulatory annotation, ClinVar pathogenicity, gnomAD frequency. Use for 'what does this SNP do', SNP-to-mechanism tracing, and resolving lead-SNP-vs-causal-variant ambiguity. Always considers LD structure before claiming a SNP is mechanistically responsible.

68

Quality

81%

Does it follow best practices?

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SecuritybySnyk

Passed

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SKILL.md
Quality
Evals
Security

Quality

Content

71%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A well-structured, actionable skill body with a clear workflow and concrete tools, weakened mainly by a dead QUICK_START.md reference and heavy inlining of material that should be split into reference files.

Suggestions

Create the referenced QUICK_START.md (or remove the dangling reference) so the 'platform-specific examples' pointer resolves to a real file.

Move the full output-format schema blocks and the interpretation guide into separate reference files, keeping only a concise summary inline in SKILL.md.

Tighten redundancy across the intro, Overview, and What It Does sections to lift conciseness toward a lean overview.

DimensionReasoningScore

Conciseness

Dense, domain-specific content that mostly earns its tokens, but the intro, Overview, What It Does, and ASCII workflow diagram each restate overlapping material that could be trimmed.

4 / 5

Actionability

Concrete tool names with real parameters, defaults, and output-schema examples make the guidance mostly executable, though examples are illustrative data shapes rather than copy-paste command sequences and LDlink is mentioned outside the tool list.

4 / 5

Workflow Clarity

A clear 5-step sequence with a tool per step and a supporting diagram; as a read-only interpretation skill it needs no destructive-validation, though explicit verify-checkpoints between steps are absent.

4 / 5

Progressive Disclosure

Section structure is reasonable, but the body references a non-existent QUICK_START.md and inlines full output-schema and interpretation-guide content that belongs in separate reference files.

3 / 5

Total

15

/

20

Passed

Description

92%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, specific description that clearly states capabilities and explicit trigger conditions with minimal conflict risk. The only weak spot is trigger-term quality, which leans on domain jargon over the natural phrases a general user might say.

DimensionReasoningScore

Specificity

Names six concrete data sources/actions (GWAS Catalog hits, LD/haplotype context, eQTL evidence, regulatory annotation, ClinVar pathogenicity, gnomAD frequency), giving comprehensive coverage of the interpretation task.

5 / 5

Completeness

Explicitly answers both 'what' (interpret a single GWAS SNP across multiple databases) and 'when' via a concrete 'Use for...' clause with multiple trigger phrases.

5 / 5

Trigger Term Quality

Includes natural phrases like 'what does this SNP do' and 'SNP-to-mechanism tracing', but leans heavily on technical jargon (eQTL, ClinVar, gnomAD) with a few common user synonyms missing.

4 / 5

Distinctiveness Conflict Risk

Occupies a clear niche (GWAS SNP interpretation with LD-aware causal-variant reasoning) with distinct triggers and minimal overlap with other skills.

5 / 5

Total

19

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

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