tooluniverse-polygenic-risk-score
Build and interpret polygenic risk scores (PRS) for complex diseases using GWAS summary statistics. Covers PRS construction (clumping/thresholding, PRS-CS), validation in independent cohorts, ancestry-aware adjustment, and clinical interpretation (population-relative risk, not absolute prediction). Use for PRS-based risk stratification.
The canonical home for this skill is tooluniverse-polygenic-risk-score in mims-harvard/ToolUniverse
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