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tooluniverse-regulatory-genomics

Transcription factor binding, cis-regulatory elements (cCREs), chromatin accessibility, and regulatory annotation using JASPAR (motifs), ENCODE (cCREs, ChIP-seq), RegulomeDB (regulatory variant scoring), UCSC — plus sequence-based deep-learning prediction of regulatory activity and non-coding variant effects (AlphaGenome, Enformer, Borzoi, ChromBPNet, Evo 2). Use for regulatory element annotation, TF-binding-site prediction, regulatory-region functional impact assessment, and predicting how a non-coding variant or a raw DNA sequence affects expression/chromatin/accessibility. Use this whenever a user asks what regulates a gene, whether a SNP hits a regulatory element, or to predict a non-coding variant's functional effect from sequence.

68

Quality

82%

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SecuritybySnyk

Passed

No findings from the security scan

SKILL.md
Quality
Evals
Security

Quality

Content

65%

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

The content is highly actionable with concrete tool calls and well-sequenced phases, but it is a dense monolithic document with some redundancy across sections and no explicit validation checkpoints or external reference files.

Suggestions

Add explicit validation/checkpoint steps (e.g., verify a returned accession exists before fetching files; confirm cCRE coordinates resolve before annotating) and a validate→fix→retry loop for risky operations to raise workflow clarity.

Move the Tool Parameter Reference table and the sequence-based deep-learning model details into separate reference files (e.g., REFERENCE.md, MODELS.md) and link to them from the body to improve progressive disclosure.

Trim redundancy by keeping each tool's parameters in one place rather than repeating them across the Key Tools table, the Workflow examples, and the Tool Parameter Reference table.

DimensionReasoningScore

Conciseness

The body is dense and mostly efficient, but tool information is restated across the Key Tools table, the Tool Parameter Reference table, and the Workflow code blocks, and the Domain Reasoning section explains concepts Claude largely already knows; it could be tightened without losing clarity.

2 / 3

Actionability

It provides concrete, executable tool calls with exact parameter values, example rsIDs/matrix_ids, documented response fields, and copy-paste-ready code blocks across every phase — fully actionable guidance.

3 / 3

Workflow Clarity

Phases 1–4 are clearly sequenced and a Fallback Strategies table exists, but there are no explicit validation/checkpoint steps or validate→fix→retry feedback loops for risky operations, so checkpoints remain implicit.

2 / 3

Progressive Disclosure

It is a well-organized single file with clear one-level sections and no nested references, but it is a long monolithic document (~330 lines) where the Tool Parameter Reference and deep-learning model details could be split into separate bundle files rather than kept inline.

2 / 3

Total

9

/

12

Passed

Description

100%

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

The description is specific, trigger-rich, and complete, clearly conveying both the skill's capabilities and the natural-language moments that should activate it. It uses appropriate third-person voice throughout.

DimensionReasoningScore

Specificity

The description lists multiple concrete actions — "Transcription factor binding, cis-regulatory elements (cCREs), chromatin accessibility, and regulatory annotation" plus "sequence-based deep-learning prediction of regulatory activity and non-coding variant effects (AlphaGenome, Enformer, Borzoi, ChromBPNet, Evo 2)" — naming specific tools and operations rather than vague language.

3 / 3

Completeness

It explicitly answers both what the skill does (annotation via JASPAR/ENCODE/RegulomeDB/UCSC plus deep-learning prediction) and when to use it via the explicit "Use this whenever a user asks..." clause, satisfying the both-what-and-when requirement.

3 / 3

Trigger Term Quality

It includes natural phrasings a user would actually say — "what regulates a gene", "whether a SNP hits a regulatory element", and "predict a non-coding variant's functional effect from sequence" — giving good coverage of realistic trigger terms.

3 / 3

Distinctiveness Conflict Risk

The regulatory-genomics niche with its specific tool list and trigger phrasings is clearly distinct and unlikely to fire for unrelated skills.

3 / 3

Total

12

/

12

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

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