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boltz-small-molecule-design

Design new small-molecule binders with Boltz. Use when generating novel ligands or hits for a target without a fixed compound library. Not for screening existing molecules or one-off docking.

69

Quality

83%

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SKILL.md
Quality
Evals
Security

Quality

Content

85%Weight 40%Scale 1-5

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A highly actionable, well-sequenced operational skill with real validation checkpoints and clean one-level-deep references to existing bundle files. The only notable weakness is redundancy: cost, range, and especially the Codex background/heartbeat guidance are repeated across multiple sections and could be consolidated.

Suggestions

State the flat $0.025/molecule cost and the 10–1,000,000 range once (in one place) and reference that line elsewhere instead of restating them in both the workflow and "Always Do This".

Consolidate the three restatements of Codex background-download behavior (step 7, the command-block comments, and the "Always Do This" bullets) into a single Codex-specific subsection or a short reference file.

Trim the overlap between "Outputs" and step 8 — both describe ranking from results/index.jsonl and point to references/results.md.

DimensionReasoningScore

Conciseness

The body avoids explaining concepts Claude already knows, but repeats the same facts across sections: the flat $0.025 cost and the 10–1,000,000 range each appear twice, and the Codex background-download/heartbeat guidance is restated in workflow step 7, the command-pattern comments, and two separate "Always Do This" bullets (lines 62 and 64). This matches anchor 3 — mostly efficient but with clear tightening opportunities — rather than anchor 2, since nothing is conceptual padding and each instance is operational.

3 / 5

Actionability

The command block is copy-paste ready with explicit placeholder-replacement instructions, concrete flag forms (--input @yaml://, --raw-output --transform id, --poll-interval-seconds 60), and covers the full common path: estimate-cost, start, download-results. It matches anchor 5 — fully executable commands covering the common cases — with the payload shape appropriately deferred to references/api.md, which contains a complete example.

5 / 5

Workflow Clarity

The 8-step sequence has explicit validation checkpoints for a costly batch operation: enforce the num_molecules range before estimate-cost, gate start on explicit cost confirmation, capture and re-use the job ID, plus error-recovery loops for missing auth (retry after boltz-cli-setup), sandbox blocks, and detached-download restart. This matches anchor 5 — clear sequence with explicit validation and feedback loops — and exceeds anchor 4, which allows minor validation gaps.

5 / 5

Progressive Disclosure

SKILL.md stays a ~78-line operational overview, and both referenced files (references/api.md, references/results.md) exist, are one level deep, self-contained, and clearly signaled at each point of use plus in a dedicated section ("Escape Hatch"). Payload and output-layout detail are correctly split out, matching anchor 5 for a bundled skill.

5 / 5

Total

18

/

20

Passed

Description

82%Weight 40%Scale 1-5

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A concise, well-scoped description with an explicit Use-when clause and a strong negative boundary that limits conflict with related screening skills. Its main weakness is thin capability coverage — it names the design action but not the cost/submit/download/rank lifecycle the skill walks through.

Suggestions

Compress the lifecycle into the first sentence, e.g. "Design new small-molecule binders with Boltz: estimate cost, submit generation runs, download ranked hits with ADME data."

Add one or two natural synonyms users might say, such as "de novo ligand design" or "generate hits for a protein target", to widen trigger coverage.

DimensionReasoningScore

Specificity

"Design new small-molecule binders with Boltz" names the domain and one concrete action, but the description stops there — no mention of costing, submitting, downloading, or ranking, which the skill actually performs. It clearly matches anchor 3 (domain plus 1-2 concrete actions, not comprehensive), not anchor 4 which requires several specific actions listed.

3 / 5

Completeness

Both parts are explicit: the what ("Design new small-molecule binders with Boltz") and the when ("Use when generating novel ligands or hits for a target without a fixed compound library"), plus a negative boundary ("Not for screening existing molecules or one-off docking"). This matches anchor 5 — concrete trigger phrases answer both what and when; it is not anchor 4 since the when-clause is already fully explicit, not merely improvable.

5 / 5

Trigger Term Quality

Good natural-term coverage: "novel ligands", "hits", "binders", "screening", "docking" are phrases users would plausibly say. It misses common variations like "de novo design", "molecule generation", or "lead discovery", so it falls just short of anchor 5's comprehensive synonym coverage.

4 / 5

Distinctiveness Conflict Risk

The explicit negative boundary ("Not for screening existing molecules or one-off docking") sharply separates it from a likely sibling screening/docking skill, and the de novo generation niche is distinct. Minimal conflict risk — anchor 5.

5 / 5

Total

17

/

20

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation — 16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
openai/plugins
Reviewed

Table of Contents

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