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openscience

github.com/synthetic-sciences/openscience

SkillAddedReview
hugging-face-tool-builder

backend/cli/skills/llm-tools/hugging-face-tool-builder/SKILL.md

Use this skill when the user wants to build tool/scripts or achieve a task where using data from the Hugging Face API would help. This is especially useful when chaining or combining API calls or the task will be repeated/automated. This Skill creates a reusable script to fetch, enrich or process data.

70

hugging-face-trackio

backend/cli/skills/other/hugging-face-trackio/SKILL.md

Track and visualize ML training experiments with Trackio. Use when logging metrics during training (Python API) or retrieving/analyzing logged metrics (CLI). Supports real-time dashboard visualization, HF Space syncing, and JSON output for automation.

76

hypogenic

backend/cli/skills/chemistry/hypogenic/SKILL.md

Automated LLM-driven hypothesis generation and testing on tabular datasets. Use when you want to systematically explore hypotheses about patterns in empirical data (e.g., deception detection, content analysis). Combines literature insights with data-driven hypothesis testing. For manual hypothesis formulation use hypothesis-generation; for creative ideation use scientific-brainstorming.

56

imaging-data-commons

backend/cli/skills/databases/imaging-data-commons/SKILL.md

Query and download public cancer imaging data from NCI Imaging Data Commons using idc-index. Use for accessing large-scale radiology (CT, MR, PET) and pathology datasets for AI training or research. No authentication required. Query by metadata, visualize in browser, check licenses.

64

immunology-assays

backend/cli/skills/biology/immunology-assays/SKILL.md

Computational analysis of immunology experimental data. ATAC-seq differential accessibility, immune cell tracking from microscopy, ELISA data processing with 4-parameter logistic fitting, immunohistochemistry quantification, antibody titer analysis, and cell cycle phase duration estimation. For flow cytometry use flow-cytometry-analysis; for scRNA-seq use scanpy.

54

implementing-llms-litgpt

backend/cli/skills/ml-training/litgpt/SKILL.md

Implements and trains LLMs using Lightning AI's LitGPT with 20+ pretrained architectures (Llama, Gemma, Phi, Qwen, Mistral). Use when need clean model implementations, educational understanding of architectures, or production fine-tuning with LoRA/QLoRA. Single-file implementations, no abstraction layers.

61

infographics

backend/cli/skills/visualization/infographics/SKILL.md

[EXPERIMENTAL] Create professional infographics using Nano Banana Pro AI with smart iterative refinement. Uses Gemini 3 Pro for quality review. Integrates research-lookup and web search for accurate data. Supports 10 infographic types, 8 industry styles, and colorblind-safe palettes.

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init

backend/cli/skills/other/init/SKILL.md

Create or refresh an AGENTS.md project instruction file. Use when starting work in a repository, onboarding an agent to an unfamiliar codebase, or when the user explicitly invokes /init or asks to initialize project guidance.

67

instructor

backend/cli/skills/llm-tools/instructor/SKILL.md

Extract structured data from LLM responses with Pydantic validation, retry failed extractions automatically, parse complex JSON with type safety, and stream partial results with Instructor - battle-tested structured output library

57

iso-13485-certification

backend/cli/skills/other/iso-13485-certification/SKILL.md

Comprehensive toolkit for preparing ISO 13485 certification documentation for medical device Quality Management Systems. Use when users need help with ISO 13485 QMS documentation, including (1) conducting gap analysis of existing documentation, (2) creating Quality Manuals, (3) developing required procedures and work instructions, (4) preparing Medical Device Files, (5) understanding ISO 13485 requirements, or (6) identifying missing documentation for medical device certification. Also use when users mention medical device regulations, QMS certification, FDA QMSR, EU MDR, or need help with quality system documentation.

64

kegg-database

backend/cli/skills/databases/kegg-database/SKILL.md

Direct REST API access to KEGG (academic use only). Pathway analysis, gene-pathway mapping, metabolic pathways, drug interactions, ID conversion. For Python workflows with multiple databases, prefer bioservices. Use this for direct HTTP/REST work or KEGG-specific control.

64

knowledge-distillation

backend/cli/skills/ml-training/knowledge-distillation/SKILL.md

Compress large language models using knowledge distillation from teacher to student models. Use when deploying smaller models with retained performance, transferring GPT-4 capabilities to open-source models, or reducing inference costs. Covers temperature scaling, soft targets, reverse KLD, logit distillation, and MiniLLM training strategies.

59

labarchive-integration

backend/cli/skills/other/labarchive-integration/SKILL.md

Electronic lab notebook API integration. Access notebooks, manage entries/attachments, backup notebooks, integrate with Protocols.io/Jupyter/REDCap, for programmatic ELN workflows.

54

lambda-gpu-cloud

backend/cli/skills/cloud-compute/lambda-labs/SKILL.md

Safely inspect and operate Lambda Cloud GPU instances through the documented Cloud API and SSH, with explicit approval before billable or destructive actions.

60

lamindb

backend/cli/skills/biology/lamindb/SKILL.md

This skill should be used when working with LaminDB, an open-source data framework for biology that makes data queryable, traceable, reproducible, and FAIR. Use when managing biological datasets (scRNA-seq, spatial, flow cytometry, etc.), tracking computational workflows, curating and validating data with biological ontologies, building data lakehouses, or ensuring data lineage and reproducibility in biological research. Covers data management, annotation, ontologies (genes, cell types, diseases, tissues), schema validation, integrations with workflow managers (Nextflow, Snakemake) and MLOps platforms (W&B, MLflow), and deployment strategies.

65

langchain

backend/cli/skills/llm-tools/langchain/SKILL.md

Framework for building LLM-powered applications with agents, chains, and RAG. Supports multiple providers (OpenAI, Anthropic, Google), 500+ integrations, ReAct agents, tool calling, memory management, and vector store retrieval. Use for building chatbots, question-answering systems, autonomous agents, or RAG applications. Best for rapid prototyping and production deployments.

61

langsmith-observability

backend/cli/skills/llm-tools/langsmith/SKILL.md

LLM observability platform for tracing, evaluation, and monitoring. Use when debugging LLM applications, evaluating model outputs against datasets, monitoring production systems, or building systematic testing pipelines for AI applications.

60

latchbio-integration

backend/cli/skills/biology/latchbio-integration/SKILL.md

Latch platform for bioinformatics workflows. Build pipelines with Latch SDK, @workflow/@task decorators, deploy serverless workflows, LatchFile/LatchDir, Nextflow/Snakemake integration.

56

latex-posters

backend/cli/skills/writing/latex-posters/SKILL.md

Create professional research posters in LaTeX using beamerposter, tikzposter, or baposter. Support for conference presentations, academic posters, and scientific communication. Includes layout design, color schemes, multi-column formats, figure integration, and poster-specific best practices for visual communication.

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liteparse

backend/cli/skills/document-parsing/liteparse/SKILL.md

Use this skill when the user asks to parse, perform multi-format document conversion or spatially extract text from an unstructured file (PDF, DOCX, PPTX, XLSX, images, etc.) locally without cloud dependencies.

65