Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.
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Low-risk findings worth noting
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Low-risk findings.
1 low severity finding. Worth noting, but not necessarily harmful.
The skill exposes the agent to untrusted, user-generated content from public third-party sources, creating a risk of indirect prompt injection. This includes browsing arbitrary URLs, reading social media posts or forum comments, and analyzing content from unknown websites.
SKILL.md describes querying/searching ClinVar via NCBI web interface (https://www.ncbi.nlm.nih.gov/clinvar/) and E-utilities (eutils.ncbi.nlm.nih.gov) with user-provided search terms and retrieving records (esummary/efetch), which at runtime can ingest ClinVar record free-text authored by third parties (e.g., submitter evidence/notes) without requiring the agent to select a specific pre-known item.
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