Content
50%Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.
The body is well-structured and grounded in concrete, executable proteomics code, but it is over-long and monolithic, with several incomplete code stubs and no validation checkpoints in the batch workflow. Splitting detailed material into referenced bundle files and tightening the prose would materially improve it.
Suggestions
Tighten conciseness: strip verbose docstrings and tutorial-style comments, and replace the ~65-line illustrative report template (with fabricated numbers) with a short structural outline or a reference file.
Fix actionability gaps: complete the stub functions (analyze_phosphosites, protein_complex_enrichment, integrate_with_multiomics) and replace the 'hypothetical' ToolUniverse tool calls with real, runnable invocations or clearly-marked placeholders.
Add validation checkpoints to the workflow: insert explicit QC gates (e.g. 'only proceed to DE analysis when missing-value rate and sample correlation pass thresholds') between phases to satisfy the batch-operation feedback-loop expectation.
Apply progressive disclosure: move the per-phase code details and report template into files under references/ or scripts/ and point to them from a concise overview in SKILL.md.
| Dimension | Reasoning | Score |
|---|---|---|
Conciseness | The ~840-line body contains executable code but is padded with verbose docstrings ('Load MaxQuant proteinGroups.txt file. Returns: DataFrame...'), explanatory comments ('# Assume missing = low abundance (MNAR assumption)'), and a ~65-line illustrative report template with hardcoded example numbers (e.g. '5,432 proteins', 'MYC (log2FC=3.2)') that do not earn their tokens; it is not score 3 because much could be tightened, and not score 1 because the core code is concrete and actionable rather than abstract filler. | 2 / 3 |
Actionability | Most phases give executable Python using real libraries (pandas, scipy, sklearn, statsmodels, networkx), but several blocks are incomplete stubs: `analyze_phosphosites` returns undefined `phospho_results` after a '# ... perform differential analysis ...' ellipsis, `protein_complex_enrichment` is a `pass` body, `integrate_with_multiomics` returns an undefined `integrated_analysis`, and `predict_kinases` calls a self-described 'hypothetical' tool; this matches score 2 (some concrete guidance but incomplete) and is not score 3 because key pieces are pseudocode/stubs. | 2 / 3 |
Workflow Clarity | The eight-phase pipeline is clearly sequenced with an ASCII workflow diagram, but explicit validation checkpoints are absent for a batch analytical operation — phases proceed with implicit assumptions (e.g. 'Should see similar median' guidance) and no 'validate QC before proceeding' gate; per the rubric's batch-operation guidance this caps the score at 2 rather than 3, and it is not 1 because the sequence itself is well laid out. | 2 / 3 |
Progressive Disclosure | No bundle files exist (no references/, scripts/, or assets/) and all content lives inline in one monolithic 840-line SKILL.md, including the full report template and per-phase code that should be split into separate referenced files; it is not score 3 because there are no one-level-deep references to separate materials, and not score 1 because the body is well-organized into labeled sections rather than a poorly organized wall of text. | 2 / 3 |
Total | 8 / 12 Passed |