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tooluniverse-variant-interpretation

Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.

68

Quality

82%

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SecuritybySnyk

Low

Low-risk findings worth noting

SKILL.md
Quality
Evals
Security

Low

Low-risk findings.

1 low severity finding. Worth noting, but not necessarily harmful.

Low

W011: Third-party content exposure detected (indirect prompt injection risk).

What this means

The skill exposes the agent to untrusted, user-generated content from public third-party sources, creating a risk of indirect prompt injection. This includes browsing arbitrary URLs, reading social media posts or forum comments, and analyzing content from unknown websites.

Why it was flagged

The required runtime workflow ingests outsider-authored free text (the user-provided gene/variant/phenotype query terms) to drive literature and database searches (e.g., PubMed/BioRxiv/MedRxiv/EuropePMC/OpenAlex/SemanticScholar searches in Phase 5), which the system then uses as query input for retrieved evidence snippets/records.

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Repository
wu-yc/LabClaw
Audited
Security analysis
Snyk

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