Code quality standards — lint (eslint/oxlint), type check (tsc), pre-commit hooks, and comment conventions. All comments must be in English.

Code quality standards — lint (eslint/oxlint), type check (tsc), pre-commit hooks, and comment conventions. All comments must be in English.

把当前对话交接给一个全新的 background agent，让它立即接手工作。

Chunked N-D arrays for cloud storage. Compressed arrays, parallel I/O, S3/GCS integration, NumPy/Dask/Xarray compatible, for large-scale scientific computing pipelines.

Access RCSB PDB for 3D protein/nucleic acid structures. Search by text/sequence/structure, download coordinates (PDB/mmCIF), retrieve metadata, for structural biology and drug discovery.

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

Query NHGRI-EBI GWAS Catalog for SNP-trait associations. Search variants by rs ID, disease/trait, gene, retrieve p-values and summary statistics, for genetic epidemiology and polygenic risk scores.

Access NCBI GEO for gene expression/genomics data. Search/download microarray and RNA-seq datasets (GSE, GSM, GPL), retrieve SOFT/Matrix files, for transcriptomics and expression analysis.

Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided dosing decisions.

Query ClinicalTrials.gov via API v2. Search trials by condition, drug, location, status, or phase. Retrieve trial details by NCT ID, export data, for clinical research and patient matching.

Medicinal chemistry filters. Apply drug-likeness rules (Lipinski, Veber), PAINS filters, structural alerts, complexity metrics, for compound prioritization and library filtering.

Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.

Parse FCS (Flow Cytometry Standard) files v2.0-3.1. Extract events as NumPy arrays, read metadata/channels, convert to CSV/DataFrame, for flow cytometry data preprocessing.

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

Use acpx as a headless ACP CLI for agent-to-agent communication, including prompt/exec/sessions workflows, session scoping, queueing, permissions, output formats, system-prompt overrides, and multi-agent flows authored with defineFlow/decision/decisionEdge.

Used to analyze Apache ShardingSphere community issues. Emphasizes root-cause-first and evidence-first classification before conclusions, and produces copy-ready GitHub issue replies in the voice of an Apache ShardingSphere community maintainer.

Migrate an Nx package to build to a local dist/ directory with nodenext module resolution, exports map, and @nx/nx-source condition.

Multi-stage pipeline for validating that vulnerability findings are real, reachable, and exploitable, preventing wasted effort on hallucinated findings, dead code paths, or findings with unrealistic preconditions.

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Systematically identify and fix all failing tests using smart grouping strategies. Use when explicitly asks to fix tests ("fix these tests", "make tests pass"), reports test failures ("tests are failing", "test suite is broken"), or completes implementation and wants tests passing.