/cs:vpe-review <plan> — Throughput-first VP of Engineering interrogation of any plan that touches delivery, eng hiring, team structure, or production discipline. Use when cycle time balloons, DORA metrics slide, or before committing to an eng hiring wave or a reorg.

VP of Engineering advisory for startups: delivery throughput (DORA 4 metrics + bottleneck identification), engineering hiring funnel (sourcing → screen → onsite → offer conversion + time-to-fill + pipeline gap), engineering team structure (squad/tribe/chapter design + tech-lead manager-trigger thresholds), and production discipline (on-call, deployment cadence, postmortem culture). Use when sprint velocity is dropping, eng hiring is broken, team structure is unclear, or deciding when to add a tech-lead manager. NOT a CTO skill (which owns architecture) — VPE owns delivery operations and how the team ships.

Detect copy number variations from whole genome sequencing data and generate publication-quality genome-wide CNV plots. Supports CNV calling, segmentation, and visualization for cancer genomics and rare disease analysis.

Use when planning video content strategy, writing video scripts, optimizing YouTube channels, building short-form video pipelines (Reels, TikTok, Shorts), or repurposing long-form content into video. Triggers: 'start a YouTube channel', 'video content strategy', 'write a video script', 'repurpose into video', 'YouTube SEO', 'short-form video'. NOT for written blog content (use content-production). NOT for social captions without video (use social-media-manager).

Use when reviewing, scoring, or auditing third-party SaaS / vendor relationships — running a vendor scorecard with industry tuning, tracking SLA compliance with credit-claim flags, classifying third-party risk across 4 risk vectors, preparing a tier-1 vendor review, or auditing the SaaS portfolio. Forks context so large vendor catalogs (50-500 line items) and SLA logs don't pollute the parent thread. Triggers on "vendor SLA", "vendor scorecard", "third-party risk", "TPRM", "vendor review", "supplier performance", "vendor health check", "renewal review".

Use when cleaning clinical trial data, preparing data for FDA/EMA submission, standardizing SDTM datasets, handling missing values in clinical studies, detecting outliers in lab results, or converting raw CRF data to CDISC format. Cleans and standardizes clinical trial data fo...

UX research and design toolkit for Senior UX Designer/Researcher including data-driven persona generation, journey mapping, usability testing frameworks, and research synthesis. Use when conducting user research, creating personas, mapping user journeys, planning usability tests, or validating designs.

Generate Circos configuration files for circular genomics data visualization. Supports genomic variations (SNPs, CNVs, structural variants), cell-cell communication networks, and custom track configurations for publication-ready circular plots.

Generate user stories with acceptance criteria and sprint planning. Usage: /user-story <generate|sprint> [options]

Use for web scraping, crawling, document extraction, API parsing, or building validation-heavy data pipelines using Firecrawl or local Python scripts.

Unified Python access to 40+ bioinformatics web services; use when you need to query multiple databases (e.g., UniProt/KEGG/ChEMBL/Reactome) with one consistent API in a single workflow, especially for cross-database analysis and identifier mapping.

UI design system toolkit for Senior UI Designer including design token generation, component documentation, responsive design calculations, and developer handoff tools. Use when creating design systems, generating design tokens, maintaining visual consistency, or facilitating design-dev collaboration and developer handoff.

Use when hunting for threats in an environment, analyzing IOCs, or detecting behavioral anomalies in telemetry. Covers hypothesis-driven threat hunting, IOC sweep generation, z-score anomaly detection, and MITRE ATT&CK-mapped signal prioritization.

Sync tests with TestRail. Use when user mentions "testrail", "test management", "test cases", "test run", "sync test cases", "push results to testrail", or "import from testrail".

A comprehensive toolbox for computational molecular biology; use it when you need programmatic sequence/structure parsing, batch bioinformatics pipelines, or automated NCBI/BLAST workflows.

Terraform infrastructure-as-code agent skill and plugin for Claude Code, Codex, Gemini CLI, Cursor, OpenClaw. Covers module design patterns, state management strategies, provider configuration, security hardening, policy-as-code with Sentinel/OPA, and CI/CD plan/apply workflows. Use when: user wants to design Terraform modules, manage state backends, review Terraform security, implement multi-region deployments, or follow IaC best practices.

Use Bio.PDB to parse and analyze protein structures (PDB/mmCIF) for structural bioinformatics tasks; use when you need structure parsing, geometry calculations, or structural comparison/superposition.

Scan, prioritize, and report technical debt. Usage: /tech-debt <scan|prioritize|report> [options]

Use Biopython to read/write/convert biological sequence files (FASTA/GenBank/FASTQ, etc.) and perform basic sequence operations; use when you need reliable sequence I/O, lightweight sequence manipulation, or scalable processing of large sequence datasets.

Scan codebases for technical debt, score severity, track trends, and generate prioritized remediation plans. Use when users mention tech debt, code quality, refactoring priority, debt scoring, cleanup sprints, or code health assessment. Also use for legacy code modernization planning and maintenance cost estimation.