Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.

Access NIH Metabolomics Workbench via REST API (4,200+ studies). Query metabolites, RefMet nomenclature, MS/NMR data, m/z searches, study metadata, for metabolomics and biomarker discovery.

Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.

Draft voice-tuned X (Twitter) post variants from a free-form brief. Reads a personal voice guide (generated via generate-voice-guide), produces 2–5 variants with distinct framings (simple-howto, problem-first, hype, mechanism-breakdown, etc.), and self-checks against the voice guide's banned phrases before returning.

Index of all COSS UI particle examples. Use when implementing UI features to find copy-paste-ready component patterns built on coss primitives. Each particle has a description and a JSON URL for easy installation.

Metabolomics research — metabolite identification, study analysis, and database searches across HMDB, MetaboLights, Metabolomics Workbench, KEGG. Use for annotating mass-spec features to known metabolites, finding metabolomics studies of a disease, and structured metabolomics research reports with metabolite-pathway mapping.

Control deep thinking mode. Default enabled. For very simple tasks (simple reminders, greetings, quick queries), can temporarily disable to speed up response. Auto-restores to enabled after completion.

Generate slide deck presentations from briefs — use when you need slides, pitch decks, or visual summaries

Create zero-context implementation plans with bite-sized tasks — use for multi-step feature planning

Process screenshot-based UI/UX feedback to fix visual issues — use when users share screenshots of bugs

Brainstorm creatively with pattern spotting and paradox hunting — use for ideation and exploration

Run a full build-and-ship pipeline from a spec — use for hands-off project generation

Extract patterns and anatomy from URLs — use to reverse-engineer content strategies from live pages

System architecture and API design with multi-AI consensus — use for design reviews and new subsystems

Set up and use 1Password CLI for sign-in, desktop integration, and reading or injecting secrets.

Create a multi-part animated story video by first establishing a consistent character and then generating sequential scenes and animating them.

Generate a 15-second cinematic awards-ceremony video — a host announces a winner from the stage, a spotlight finds them in the crowd, they walk up to the podium, receive the award, and the LED display reveals their name and "THE BEST ACTOR".

Meme coin and token security audit — rug pull detection (honeypot, hidden mint, fee manipulation, LP lock bypass), Solana SPL token analysis (freeze authority, mint authority, metadata mutability), Token-2022 extension risks (transfer hooks, permanent delegate), DEX liquidity pool attacks (sandwich amplification, LP drain, bonding curve exploits), pump.fun/Raydium/Jupiter integration risks, token_scanner.py automation, and real exploit examples from 2024-2025. Use for any token audit, rug pull assessment, meme coin security review, or pre-investment due diligence.

Primary accessibility skill for VS Code. REQUIRED for new feature and contribution work, and also applies to updates of existing UI. Covers accessibility help dialogs, accessible views, verbosity settings, signals, ARIA announcements, keyboard navigation, and ARIA labels/roles.

指导如何在 Project Graph 项目中创建新的设置项。当用户需要添加新的设置项、配置选项或需要了解设置系统的实现方式时使用此技能。