Evaluates the quality of cohort studies using the Newcastle-Ottawa Scale (NOS). Use when the user provides a cohort study article or text and needs a quality assessment report.

Use when someone wants to run a weekly review, close open loops, audit stalled projects and commitments, get their system back to trusted, restart a lapsed review habit, or says "/cs:weekly-review". Walks David Allen's three-phase loop — GET CLEAR, GET CURRENT, GET CREATIVE — with deterministic scripts that inventory open loops, gate the checklist with named gaps, and score commitment health 0-100.

Use when refactoring research code for publication, adding documentation to existing analysis scripts, creating reproducible computational workflows, or preparing code for sharing with collaborators. Transforms research code into publication-ready, reproducible workflows. Adds documentation, implements error handling, creates environment specifications, and ensures computational reproducibility for scientific publications.

When the user wants to plan, promote, run, or improve a webinar or virtual event to generate and convert demand. Use when the user mentions 'webinar,' 'virtual event,' 'online event,' 'live demo,' 'virtual summit,' 'workshop,' 'masterclass,' 'fireside chat,' 'roundtable,' 'registration funnel,' 'show-up rate,' 'attendance rate,' 'webinar promotion,' 'webinar follow-up,' or 'on-demand webinar.' Also use when they have a webinar that isn't converting — low registrations, low show-up, or attendees who don't buy — and want to diagnose and fix it. Covers the full funnel: registration, promotion, show-up, live engagement, live-to-close, and post-event nurture. Distinct from launch-strategy (full product launches) and email-sequence (lifecycle nurture) — this is the end-to-end webinar/event motion. NOT for in-person field events logistics, and NOT for generic lifecycle email (use email-sequence).

Constraint-based reconstruction and analysis (COBRA) for metabolic models; use when you need to simulate growth/production, analyze flux ranges, or run knockout and medium studies from SBML/JSON/YAML models.

/cs:vpe-review <plan> — Throughput-first VP of Engineering interrogation of any plan that touches delivery, eng hiring, team structure, or production discipline. Use when cycle time balloons, DORA metrics slide, or before committing to an eng hiring wave or a reorg.

VP of Engineering advisory for startups: delivery throughput (DORA 4 metrics + bottleneck identification), engineering hiring funnel (sourcing → screen → onsite → offer conversion + time-to-fill + pipeline gap), engineering team structure (squad/tribe/chapter design + tech-lead manager-trigger thresholds), and production discipline (on-call, deployment cadence, postmortem culture). Use when sprint velocity is dropping, eng hiring is broken, team structure is unclear, or deciding when to add a tech-lead manager. NOT a CTO skill (which owns architecture) — VPE owns delivery operations and how the team ships.

Detect copy number variations from whole genome sequencing data and generate publication-quality genome-wide CNV plots. Supports CNV calling, segmentation, and visualization for cancer genomics and rare disease analysis.

Use when planning video content strategy, writing video scripts, optimizing YouTube channels, building short-form video pipelines (Reels, TikTok, Shorts), or repurposing long-form content into video. Triggers: 'start a YouTube channel', 'video content strategy', 'write a video script', 'repurpose into video', 'YouTube SEO', 'short-form video'. NOT for written blog content (use content-production). NOT for social captions without video (use social-media-manager).

Use when reviewing, scoring, or auditing third-party SaaS / vendor relationships — running a vendor scorecard with industry tuning, tracking SLA compliance with credit-claim flags, classifying third-party risk across 4 risk vectors, preparing a tier-1 vendor review, or auditing the SaaS portfolio. Forks context so large vendor catalogs (50-500 line items) and SLA logs don't pollute the parent thread. Triggers on "vendor SLA", "vendor scorecard", "third-party risk", "TPRM", "vendor review", "supplier performance", "vendor health check", "renewal review".

Use when cleaning clinical trial data, preparing data for FDA/EMA submission, standardizing SDTM datasets, handling missing values in clinical studies, detecting outliers in lab results, or converting raw CRF data to CDISC format. Cleans and standardizes clinical trial data fo...

UX research and design toolkit for Senior UX Designer/Researcher including data-driven persona generation, journey mapping, usability testing frameworks, and research synthesis. Use when conducting user research, creating personas, mapping user journeys, planning usability tests, or validating designs.

Generate Circos configuration files for circular genomics data visualization. Supports genomic variations (SNPs, CNVs, structural variants), cell-cell communication networks, and custom track configurations for publication-ready circular plots.

Generate user stories with acceptance criteria and sprint planning. Usage: /user-story <generate|sprint> [options]

Use for web scraping, crawling, document extraction, API parsing, or building validation-heavy data pipelines using Firecrawl or local Python scripts.

Unified Python access to 40+ bioinformatics web services; use when you need to query multiple databases (e.g., UniProt/KEGG/ChEMBL/Reactome) with one consistent API in a single workflow, especially for cross-database analysis and identifier mapping.

UI design system toolkit for Senior UI Designer including design token generation, component documentation, responsive design calculations, and developer handoff tools. Use when creating design systems, generating design tokens, maintaining visual consistency, or facilitating design-dev collaboration and developer handoff.

Use when hunting for threats in an environment, analyzing IOCs, or detecting behavioral anomalies in telemetry. Covers hypothesis-driven threat hunting, IOC sweep generation, z-score anomaly detection, and MITRE ATT&CK-mapped signal prioritization.

Sync tests with TestRail. Use when user mentions "testrail", "test management", "test cases", "test run", "sync test cases", "push results to testrail", or "import from testrail".

A comprehensive toolbox for computational molecular biology; use it when you need programmatic sequence/structure parsing, batch bioinformatics pipelines, or automated NCBI/BLAST workflows.