Find the real protein target(s) of a peptide from its sequence — peptide target deorphanization / off-target identification, for ANY target class (GPCR, ion channel, protease, cytokine/growth-factor receptor, enzyme, integrin), not only GPCRs. Use when a peptide has a phenotype but does not bind its hypothesized target, when a peptide binds a target in one species or assay but not another, or to screen candidate targets for an orphan peptide. A target-class router steers a multi-route keyless pipeline (PROSITE/ELM motif, BLAST homology, HGNC/InterPro/GPCRdb/GtoPdb target-family enumeration, OpenTargets phenotype anchor, EnsemblCompara/Alliance cross-species reconciliation) plus optional NVIDIA-NIM co-folding (Boltz2, AlphaFold2-Multimer, OpenFold3) for structural confirmation.

Cancer cell-line selection and profiling for experimental model choice. Cross-references DepMap, Cellosaurus, COSMIC, PharmacoDB to deliver identity verification, mutation/CNV profile, gene dependencies, drug sensitivities, and druggable targets. Use to answer 'which cell line should I use for studying gene X?' or 'is this cell line a good model for cancer Y?'. Outputs ranked recommendations with rationale, growth characteristics, and known pitfalls.

Systematic ACMG/AMP germline variant classification with all 28 criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) for clinical significance. Produces 5-tier verdict (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with cited evidence per criterion. Use for variant interpretation, VUS resolution, and pathogenicity assessment. Combines ClinVar, gnomAD, computational predictors, and gene-mechanism context.

Guided journey from a live website that underperforms to a prioritized, evidence-backed backlog of conversion, usability, message, and speed fixes - each shipped as a testable experiment. Orchestrates eight skills phase by phase - cro-methodology, ux-heuristics, refactoring-ui, web-typography, storybrand-messaging, high-perf-browser, made-to-stick, design-everyday-things - asking the user questions at every decision point and recording results in the project docs/ folder (WEBSITE.md, DESIGN.md, IMPROVE-WEBSITE-PLAN.md) so the journey resumes across sessions. Use when the user wants to fix a landing page that isn't converting, diagnose why visitors leave, audit for clarity and usability, or says 'the homepage feels off but a redesign didn't help'. No site yet, create-website; converts but needs traffic, grow-website; if the friction is in a product app, not the marketing site, improve-app; if one specific flow leaks, conversion-optimization. For one framework in isolation, invoke that skill directly.

Guided journey from a live website that underperforms to a prioritized, evidence-backed backlog of conversion, usability, message, and speed fixes - each shipped as a testable experiment. Orchestrates eight skills phase by phase - cro-methodology, ux-heuristics, refactoring-ui, web-typography, storybrand-messaging, high-perf-browser, made-to-stick, design-everyday-things - asking the user questions at every decision point and recording results in the project docs/ folder (WEBSITE.md, DESIGN.md, IMPROVE-WEBSITE-PLAN.md) so the journey resumes across sessions. Use when the user wants to fix a landing page that isn't converting, diagnose why visitors leave, audit for clarity and usability, or says 'the homepage feels off but a redesign didn't help'. No site yet, create-website; converts but needs traffic, grow-website; if the friction is in a product app, not the marketing site, improve-app; if one specific flow leaks, conversion-optimization. For one framework in isolation, invoke that skill directly.

Guided journey from a working-but-untested vibe-coded prototype to a production-ready product with tests, clean structure, a business-rules boundary, and resilience at scale. Orchestrates nine skills phase by phase - working-with-legacy-code, clean-code, refactoring-patterns, software-design-philosophy, clean-architecture, pragmatic-programmer, release-it, system-design, ddia-systems - asking the user questions at every decision point and recording results in the project docs/ folder (TESTING.md, TECH-DEBT.md, IMPROVE-CODE-QUALITY-PLAN.md) so the journey resumes across sessions. Use when the user wants to harden an AI-generated prototype, add tests before refactoring, make code safe to change, or says 'this works on my machine but I am scared to touch it'. For an aged codebase, remove-technical-debt; for greenfield structure, design-code-architecture; for a product and UX pass, improve-app; to optimize speed and structure, architecture-optimization. For one framework in isolation, invoke that skill directly.

A step-by-step problem-solving loop (classify the ask, define done, gather evidence, decide, act surgically, verify by observation, report outcome-first). Use when the user says "/fable-method", "use the fable method", or "approach this like Fable", or proactively when starting any multi-step task that no task-specific skill covers. Subcommands - plan (stop after the plan), audit (grade finished work against the loop), report (rewrite an answer outcome-first).

Authors, refactors, and consolidates Agent Skills PRP-style. Use when the user wants to "create a skill", "write a new skill", "trim a SKILL.md", "split a skill into references", "consolidate workflow skills", "replace duplicated skill logic with composition", redesign a skill workflow, or invokes /prp-meta-skill.

Authors, refactors, and consolidates Agent Skills PRP-style. Use when the user wants to "create a skill", "write a new skill", "trim a SKILL.md", "split a skill into references", "consolidate workflow skills", "replace duplicated skill logic with composition", redesign a skill workflow, or invokes /prp-meta-skill.

Creates an implementation-ready plan for a feature, bug fix, refactor, or chore from a PRD, issue, document, or description using codebase evidence, first-principles reasoning, and conditional root-cause analysis, research, or spikes. Publishes issue-derived plans back to their source issue. Use when the user asks to "plan this feature", "plan this bug fix", "plan issue X", "create an implementation plan", "turn this PRD into a plan", investigate how a change should be built, link related plans, or invokes $prp-plan.

Autonomously owns one workstream from an issue, PRD, document, existing plan, or free-form request through planning, implementation, pull request, independent review, corrections, and green CI. Always use when the user asks to implement or ship work end to end, take an issue or idea to a reviewed PR, run plan to PR, invokes $prp-issue, or when prp-orchestrate needs an end-to-end delivery engine.

Decide whether Chatto client code goes into `@chatto/client` (packages/chatto-client) or the bundled frontend (apps/frontend). Use before you add a request, store, state, helper, or protocol rule to either, or when you move code between them.

Fetch unread GitHub notifications for open PRs where review is requested from a specified team or opened by a team member. Use when asked to "find PRs I need to review", "show my review requests", "what needs my review", "fetch GitHub review requests", or "check team review queue".

Django performance code review. Use when asked to "review Django performance", "find N+1 queries", "optimize Django", "check queryset performance", "database performance", "Django ORM issues", or audit Django code for performance problems.

Writes Specific Aims pages for grant applications. Use when drafting or revising the Specific Aims page (NIH R01/R21/R03), NSF Project Summary, or equivalent for any major funding agency. Also triggers on "write my specific aims", "help me draft specific aims for NIH", "what should a specific aims page include", "NSF project summary", "write my grant aims", or "how do I structure an R01".

Use this skill when the user asks whether artists, albums, or tracks are available in the configured Plex music library; wants to search Plex music metadata; asks about listened state, release years/dates, genres, library sections, MusicBrainz/Plex GUIDs, or local music library locations. This skill uses read-only Plex HTTP API requests through bundled scripts. Do not use this skill for online music reference metadata, lyrics, downloads, playback control, metadata edits, library refreshes, or movie/TV questions.

当用户要对 OpenLoaf 的"项目"这一实体做创建、打开、切换、移动、删除、改名时触发。典型说法"新建项目"、"把 ~/code/foo 加进来"、"列出所有项目"。**不用于**：项目内文件读写（→直接用 Read/Edit/Write）、讨论"项目规划 / 需求文档"（→直接回答）、纯 Git 日常操作（→`Bash`）。

Runs Snyk CLI security scans and fixes the vulnerabilities found. Covers four domains: source code (SAST via snyk code test), open-source dependencies (SCA via snyk test), container images (snyk container test), and infrastructure-as-code files such as Terraform, Kubernetes YAML, and CloudFormation (snyk iac test). Use this skill whenever the user wants to scan for vulnerabilities, audit dependencies, secure a Dockerfile or container image, check IaC for misconfigurations, or asks "is my code/app/image/infra secure?". Also trigger for requests like "fix security issues", "run a security scan", "check for CVEs", "find hardcoded secrets", or "review my Terraform for security problems" even if Snyk is not mentioned by name.

Create a GitHub PR from the current branch: handle uncommitted changes, generate a summary, and submit via gh CLI. Use when the user says "create PR", "open PR", "submit PR", "push PR", or wants to create a pull request.

Point an external editor or app — VS Code, Cursor, Claude Desktop, or ChatGPT — at a running Docker Sandbox over SSH via the `<name>.sbx` hostname, so the tool's UI stays on the host while files and processes run inside the sandbox. Use when setting up `sbx setup ssh`, wiring a remote-SSH connection in one of those apps, hitting a stalled or looping connection, or deciding whether Claude Desktop's credential-isolation warning applies to a given setup.