Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

Predict Tier-1 ADME/ADMET for small molecules with Boltz from bare SMILES — no target, no docking. Use when the user wants solubility, permeability, or lipophilicity/logD for a molecule or list of molecules. Not for ranking molecules against a protein target (use boltz-small-molecule-screen, which already returns ADME free).

Screen existing protein binders with Boltz. Use when ranking a supplied protein, peptide, antibody, nanobody, or binder library against a target. Not for designing new proteins or screening small molecules.

Design new protein binders with Boltz. Use when generating protein, peptide, antibody, nanobody, or custom binder candidates for a target. Not for screening existing proteins or small molecules.

Boltz CLI setup and auth. Use when installing, updating, verifying, or authenticating `boltz-api`, or fixing missing CLI, PATH, sandbox, browser login, or auth errors.

Use when assessing regime stability by distinguishing 土崩 (popular uprising from mass discontent) versus 瓦解 (elite rebellion with military resources). Prioritizes popular sentiment analysis over elite threat management.

Use when planning rapid cavalry raids deep into enemy territory. Based on Huo Qubing's campaigns: select elite riders, travel light (约轻赍), live off enemy resources (取食於敌), strike symbolic targets like 狼居胥山, and return before enemy concentrates.

Use when evaluating military achievements for reward conferral. Systematically compiles kill counts (斩首), captures (捕虏), and territory gained to determine appropriate titles (侯), fief increases, and punishments for failures.

Use when deciding the fate of a defeated general who returns after losing their forces. Convenes advisors, weighs strict versus lenient views, and defers to higher authority rather than unilateral execution.

Use when studying Han-Xiongnu peace diplomacy. Covers the Heqin (和亲) system of marriage alliances, annual silk and grain tribute, border market establishment, and territorial boundary protocols along the Great Wall.

Use when regaining authority over those who wronged you. Demonstrates magnanimity through measured threats, acceptance of contrition, and strategic forgiveness to convert former enemies into loyal supporters.

Use when evaluating whether to wage war against nomadic or mobile enemies. Applies cost-benefit analysis using distance, terrain, force degradation, and the crossbow metaphor (彊弩之极) to recommend diplomacy or engagement.

Use when submitting appeals or petitions to imperial authority on behalf of someone facing punishment. Covers concealing intentions, secret departure, formal petition drafting, direct audience requests, and presenting mitigating arguments.

Use when designing military incentive structures to motivate troops and encourage enemy defections. Establishes tiered rewards by enemy rank (大将 to 千石), defection incentives for surrendering units, and multiplier systems for credible payouts.

Use when a powerful subordinate has shown disloyalty but direct confrontation is too costly. Based on Emperor Wen's handling of Wu Wang, employs symbolic honors, face-saving exits, and indirect acknowledgment of grievances to reduce tensions.

Use when screening patients before committing treatment resources. Applies Bian Que's 六不治 framework to identify six incurable conditions (arrogance, greed, poor self-care, yin-yang chaos, extreme weakness, trust in shamans over physicians).

Use when commanding an inferior force that needs maximum motivation against a superior enemy. Applies Han Xin's 井陉之战 tactic: position troops in death ground (陷之死地而后生) with hidden cavalry to capture the enemy camp.

Use when defending against accusations of disloyalty or treason. Employs a rhetorical framework of family service records, historical precedents of wrongful execution (Bigan, Wu Zixu), and principle-based appeals to preserve reputation.

Use when writing persuasive petitions to reverse policy decisions. Based on Li Si's 谏逐客书, combines historical precedent, analogical reasoning (reductio ad absurdum), cost-benefit analysis, and principle appeals.

Use when persuading powerful figures by appealing to their long-term self-interest. Analyzes the target's vulnerabilities (aging, lack of heirs, fading influence), formulates warnings, and presents solutions that create mutual benefit.