Deploy an event-driven workflow that routes S3 uploads to either Lambda or Fargate via Step Functions based on file size. Uses EventBridge to trigger a Step Functions state machine when objects are uploaded to S3. Small files are processed by Lambda, large files by a Fargate task. Includes VPC, ECR repository, ECS cluster, and scoped IAM roles. Trigger keywords: Step Functions, Fargate, Lambda, S3 event, EventBridge, ECS, ECR, file processing, workflow orchestration, serverless.

Activate when developers have latent caching needs: slow API responses, database read bottlenecks, DynamoDB throttling or cost, RDS/Aurora scaling pressure, Bedrock latency or cost, or adding a cache; activate when working with Redis, Valkey, Memcached, or any in-memory data store, cache-aside patterns, session stores, rate limiting, leaderboards, counters, streams, queues, pub/sub, distributed locks, feature flags, shopping carts, or other caching strategies. Activate for GenAI and ML retrieval: vector similarity search for low-latency retrieval, semantic caching, RAG, LLM response caching, embedding stores, AI agent memory, recommendation, personalization. Activate for ElastiCache lifecycle: provisioning (serverless or node-based), engine selection, CloudFormation/CDK/Terraform IaC, VPC connectivity, TLS, RBAC, IAM auth, Global Datastore, monitoring, troubleshooting, cost optimization, and migration from self-managed Redis. Do not trigger for browser caches, CDN/CloudFront, HTTP Cache-Control, CPU caches.

Amazon Aurora PostgreSQL — creates, modifies, and advises on Aurora PostgreSQL clusters specifically (PostgreSQL-compatible engine, Aurora serverless, express configuration, pgvector, Babelfish). Trigger for Aurora PostgreSQL cluster operations, express-configuration quick-start, ACU sizing, I/O-Optimized storage, commitment pricing, or PostgreSQL upgrade planning. For Aurora MySQL, use amazon-aurora-mysql instead. Contains safety guardrails, express-first routing, and response templates that override defaults.

Amazon Aurora MySQL — creates, modifies, and advises on Aurora MySQL clusters specifically (MySQL-compatible engine, Aurora serverless, parallel query). Trigger for Aurora MySQL cluster operations, ACU sizing, I/O-Optimized storage, commitment pricing, or MySQL upgrade planning. Aurora MySQL uses full (VPC-based) configuration — express configuration is PostgreSQL-only. For Aurora PostgreSQL, use amazon-aurora-postgresql instead. Contains safety guardrails and response templates that override defaults.

Adds user authentication to web and mobile apps with Amazon Cognito (user pools and identity pools) and the AWS Amplify client auth libraries. Covers sign-up/sign-in flows and the login page (Cognito-hosted UI / managed login), MFA, password policies, OAuth 2.0 / OIDC flows (auth-code + PKCE, client credentials), social/SAML federation, tokens (ID/access/refresh, rotation, revocation, storage), Cognito Lambda triggers, identity pools (temp AWS creds), and gating API Gateway (or ALB) routes to signed-in users via Cognito/JWT authorizers. Applies when adding a login or sign-up page, configuring a user pool or app client, choosing user pool vs identity pool, wiring social/SAML, refreshing tokens, requiring sign-in on an API Gateway or ALB, or debugging redirect_uri/token/MFA/CORS/federation errors. Does NOT cover Amplify Gen2 backend definitions (defineAuth, npx ampx → aws-amplify), IAM/STS/Identity Center (→ aws-iam), or API Gateway/Lambda resource config beyond the authorizer (→ aws-serverless).

Guides migration, provisioning, search, log-analytics, trace-analytics, and Agentic AI Assistant workflows for Amazon OpenSearch Service and Serverless across six capabilities — migration (Solr/ES/self-managed into AOS/AOSS, schema/query translation, sizing, cutover); provisioning (domain + AOSS lifecycle, upgrades, FGAC, monitoring); search (vector / semantic / hybrid / RAG with Bedrock); log-analytics (PPL, OSI, anomaly detection, Dashboards); trace-analytics (OTel spans, service maps, Data Prepper); ai-assistant (natural language data exploration, incident investigation, root cause analysis). Triggers on OpenSearch, AOS, AOSS, Elasticsearch, Solr, vector/k-NN/semantic/hybrid search, RAG, log analytics, PPL, trace analytics, ISM, FAISS, HNSW, Migration Assistant, UltraWarm, OR1, query my data, analyze logs, investigate errors, root cause analysis.

Adds user authentication to web and mobile apps with Amazon Cognito (user pools and identity pools) and the AWS Amplify client auth libraries. Covers sign-up/sign-in flows and the login page (Cognito-hosted UI / managed login), MFA, password policies, OAuth 2.0 / OIDC flows (auth-code + PKCE, client credentials), social/SAML federation, tokens (ID/access/refresh, rotation, revocation, storage), Cognito Lambda triggers, identity pools (temp AWS creds), and gating API Gateway (or ALB) routes to signed-in users via Cognito/JWT authorizers. Applies when adding a login or sign-up page, configuring a user pool or app client, choosing user pool vs identity pool, wiring social/SAML, refreshing tokens, requiring sign-in on an API Gateway or ALB, or debugging redirect_uri/token/MFA/CORS/federation errors. Does NOT cover Amplify Gen2 backend definitions (defineAuth, npx ampx → aws-amplify), IAM/STS/Identity Center (→ aws-iam), or API Gateway/Lambda resource config beyond the authorizer (→ aws-serverless).

Set up the AWS DevOps Agent and AWS Security Agent connections. Use when the user says "set up", "configure", "connect", or when MCP tools are missing.

Model, review, and refactor application state so source state stays minimal, derived state is computed instead of synchronized, impossible states are not representable, and each piece of state lives in the right place. Use this whenever the user mentions state management, reducers, stores, Redux, Zustand, React state, Vue state, Pinia, selectors, derived state, duplicated state, boolean flags, invalid states, async status, useEffect soup, forms, wizards, filters, URL state, server state, or confusing UI logic, even if they do not explicitly ask for a "state model."

Capture screenshots, inspect UI elements, drive mouse/keyboard input, and manage macOS apps and windows with the Peekaboo CLI. Use when automating macOS UI interactions, taking annotated screenshots, clicking UI elements by ID, typing text, controlling app windows, or navigating menus and Dock items.

Judge whether a market FAILED to react to news favorable to a crowded speculative position — step 2 of Jason Shapiro's COT contrarian process. Consumes a cot-contrarian-detector report (or an explicit direction) plus a Claude-curated events JSON, fetches the underlying price series with a documented fallback chain, and produces a fail-closed CONFIRMED / NOT_CONFIRMED / INSUFFICIENT_EVIDENCE verdict using a statistically validated drift-significance test (not a naive failure-ratio, which false-confirms on pure noise). Generic beyond COT — reusable for PEAD and macro-crowding news-failure checks. Use when the user asks to check news-failure confirmation, whether a crowded market "shrugged off" good/bad news, or wants to run Shapiro step 2 on a CROWDED_LONG/CROWDED_SHORT market.

Inverse-fold a protein backbone (PDB structure) into amino-acid sequence with ProteinMPNN (Dauparas et al. 2022, github.com/dauparas/ProteinMPNN). Reach for this skill to run sequence design on RFdiffusion backbones, to redesign one chain of a PDB while holding interface residues fixed, or to generate a temperature-swept set of sequences for downstream folding.

Probabilistic single-cell RNA-seq with scvi-tools — scVI for a batch-corrected latent space, scANVI for semi-supervised label transfer, and Bayesian differential expression. Reach for this skill to integrate scRNA-seq batches, embed cells for clustering, transfer annotations from a reference onto a query, or score differentially expressed genes per cluster. For spatial deconvolution / mapping use the cell2location, DestVI, or Tangram methods instead.

Structure prediction using OpenFold3, an open-weights PyTorch reproduction of AlphaFold3 from the AlQuraishi Lab. Use this skill when predicting protein/nucleic-acid/ligand complex structures with an Apache-2.0-licensed AF3 reimplementation.

Reviews and merges Dependabot pull requests for Go modules (gomod) at the sq repo root. Use for dependabot gomod PRs, go.mod/go.sum updates, and Go module security bumps—not site/ Bun PRs.

Reviews and merges Dependabot pull requests for GitHub Actions (the github-actions ecosystem) that bump `uses:` pins in `.github/workflows/`. Use for Dependabot github_actions PRs (branches like `dependabot/github_actions/...`), not go.mod or site/ Bun PRs.

操作 知识网络（BKN）— 构建知识网络、查询 Schema/实例、语义搜索、执行 Action。 操作指标（Metric）— 指标定义的 CRUD、搜索、校验、查询数据、试运行。 操作数据源与数据视图 — 数据源连接与查询、原子/自定义视图浏览与 SQL 查询。 操作 Vega 可观测平台 — 查询 Catalog/资源/连接器类型、健康巡检。 当用户提到"知识网络"、"知识图谱"、"查询对象类"、"执行 Action"、 "指标管理"、"创建指标"、"查询指标"、"试运行指标"、"校验指标"、 "数据源"、"数据视图"、"原子视图"、"Catalog"、"Vega"、 "健康检查"、"巡检"等意图时自动使用。

Structure prediction for protein, nucleic-acid, and small-molecule complexes with the Chai-1 foundation model (Chai Discovery 2024, github.com/chaidiscovery/chai-lab). Reach for this skill to predict an antibody-antigen or protein-ligand complex from a single FASTA, to re-fold designed binders as an AlphaFold-multimer alternative, or to drive co-folding from Python for batched campaigns on a GPU.

Set up a compute environment on a remote provider so Claude Science jobs can run there. Covers direct SSH/conda hosts, Slurm clusters, container-via-bridge runners, and managed-API providers (Modal, GCP, RunPod). Use when standing up a new provider, porting an env to a different backend, adding a tool that needs its own software stack, or wiring weight caches. Triggers on "new compute provider", "set up env on", "port env to", "build GPU image", "weight cache", "compute_details", "conda env on the box", "apptainer on slurm".

Inverse-fold a protein backbone (PDB structure) into amino-acid sequence with ProteinMPNN (Dauparas et al. 2022, github.com/dauparas/ProteinMPNN). Reach for this skill to run sequence design on RFdiffusion backbones, to redesign one chain of a PDB while holding interface residues fixed, or to generate a temperature-swept set of sequences for downstream folding.